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CDC42 Effector Protein 2 (CDC42EP2)

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BORG1; CEP2; CRIB-Containing BOGR1 Protein; Binder of Rho GTPases 1

CDC42 Effector Protein 2 (CDC42EP2)
CCC J476
HGNC 16263
MGI 1929744
PubMed 11584266
RGD 1310253
UniProt O14613
Wiki CDC42EP2
CDC42EP2 is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of, CDC42. Coexpression of this protein with dominant negative mutant CDC42 protein in fibroblast was found to induce pseudopodia formation, which suggested a role of this protein in actin filament assembly and cell shape control.
Sequence analysis predicted that the 210-amino acid BORG1 protein contains a CRIB motif followed by a conserved 12-residue BORG homology-1 (BH1) domain in its N terminus; an 11-amino acid BH2 domain in its central region; and a 22-residue BH3 domain in its C terminus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CDC42 Effector Protein 2 (CDC42EP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CDC42 Effector Protein 2 (CDC42EP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CDC42 Effector Protein 2 (CDC42EP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CDC42 Effector Protein 2 (CDC42EP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for CDC42 Effector Protein 2 (CDC42EP2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CDC42 Effector Protein 2 (CDC42EP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CDC42 Effector Protein 2 (CDC42EP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CDC42 Effector Protein 2 (CDC42EP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CDC42 Effector Protein 2 (CDC42EP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for CDC42 Effector Protein 2 (CDC42EP2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CDC42 Effector Protein 2 (CDC42EP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CDC42 Effector Protein 2 (CDC42EP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CDC42 Effector Protein 2 (CDC42EP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CDC42 Effector Protein 2 (CDC42EP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for CDC42 Effector Protein 2 (CDC42EP2) ELISA Kit Customized Service Offer
  1. "A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus."Genome Res. 7:725-735(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins."Mol. Cell. Biol. 19:6585-6597(1999) [PubMed] [Europe PMC] [Abstract]
  3. "A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes."J. Biol. Chem. 276:875-883(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Borg proteins control septin organization and are negatively regulated by Cdc42."Nat. Cell Biol. 3:861-866(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]