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CDC42 Effector Protein 4 (CDC42EP4)

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CEP4; BORG4; Binder Of Rho GTPases 4

CDC42 Effector Protein 4 (CDC42EP4)
CCC J474
HGNC 17147
MGI 1929760
PubMed 23994638
RGD 1588736
UniProt Q9H3Q1
Wiki CDC42EP4
CDC42EP4 is a member of the CDC42-binding protein family. This protein has been shown to bind both CDC42 and TC10 GTPases in a GTP-dependent manner. When overexpressed in fibroblasts, this protein was able to induce pseudopodia formation, which suggested a role in inducing actin filament assembly and cell shape control.
BORG4 shares highly conserved CRIB, BH1, and BH3 domains, and a less well-conserved BH2 domain. RT-PCR analysis showed that Borg4 is expressed ubiquitously at low levels in adult mouse tissues.the 356-amino acid CEP4 protein contains a conserved BH2, or CI, domain; binds through its CRIB domain with CDC42 but not with RAC; induces pseudopodia formation; and is expressed in fibroblast cytoplasm and membrane.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CDC42 Effector Protein 4 (CDC42EP4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CDC42 Effector Protein 4 (CDC42EP4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CDC42 Effector Protein 4 (CDC42EP4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CDC42 Effector Protein 4 (CDC42EP4) CLIA Kit Customized Service Offer
n/a ELISA Kit for CDC42 Effector Protein 4 (CDC42EP4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CDC42 Effector Protein 4 (CDC42EP4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CDC42 Effector Protein 4 (CDC42EP4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CDC42 Effector Protein 4 (CDC42EP4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CDC42 Effector Protein 4 (CDC42EP4) CLIA Kit Customized Service Offer
n/a ELISA Kit for CDC42 Effector Protein 4 (CDC42EP4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CDC42 Effector Protein 4 (CDC42EP4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CDC42 Effector Protein 4 (CDC42EP4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CDC42 Effector Protein 4 (CDC42EP4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CDC42 Effector Protein 4 (CDC42EP4) CLIA Kit Customized Service Offer
n/a ELISA Kit for CDC42 Effector Protein 4 (CDC42EP4) ELISA Kit Customized Service Offer
  1. "Sequence analysis, gene expression, and chromosomal assignment of mouse Borg4 gene and its human orthologue."J. Hum. Genet. 45:374-377(2000) [PubMed] [Europe PMC] [Abstract]
  2. "A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes."J. Biol. Chem. 276:875-883(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]