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Slingshot Homolog 1 (SSH1)

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SSH1L; SSH-like protein 1; Protein phosphatase Slingshot homolog 1

Slingshot Homolog 1 (SSH1)
CCC J456
HGNC 30579
MGI 2686240
PubMed 22496574
RGD 1306038
UniProt Q8WYL5
Wiki SSH1
The ADF (actin-depolymerizing factor)/cofilin family is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo. Transcript analysis suggested that at least 6 polypeptides would be produced from these genes. SSH1 encodes 3 isoforms, SSH1L (1,049 amino acids), SSH1S (692 amino acids), and SSH1B (148 amino acids), and SSH2 encodes 2 isoforms, SSH2 (449 amino acids) and SSH2B (195 amino acids). The SSH3 protein has 471 amino acids. Besides the catalytic domain, 2 other domains are conserved between Drosophila ssh and the human SSHs and are unique to the SSH family.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ456Hu01 Recombinant Slingshot Homolog 1 (SSH1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAJ456Hu21 Monoclonal Antibody to Slingshot Homolog 1 (SSH1) WB; IHC; ICC; IP.
PAJ456Hu01 Polyclonal Antibody to Slingshot Homolog 1 (SSH1) WB; IHC; ICC; IP.
Assay Kits SEJ456Hu ELISA Kit for Slingshot Homolog 1 (SSH1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Slingshot Homolog 1 (SSH1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Slingshot Homolog 1 (SSH1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Slingshot Homolog 1 (SSH1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Slingshot Homolog 1 (SSH1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Slingshot Homolog 1 (SSH1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Slingshot Homolog 1 (SSH1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Slingshot Homolog 1 (SSH1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Slingshot Homolog 1 (SSH1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Slingshot Homolog 1 (SSH1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Slingshot Homolog 1 (SSH1) ELISA Kit Customized Service Offer
  1. "Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin."Cell 108:233-246(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin."Genes Cells 8:811-824(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Cell cycle-associated changes in Slingshot phosphatase activity and roles in cytokinesis in animal cells."J. Biol. Chem. 278:33450-33455(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Control of growth cone motility and morphology by LIM kinase and Slingshot via phosphorylation and dephosphorylation of cofilin."J. Neurosci. 23:2527-2537(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Efficient Salmonella entry requires activity cycles of host ADF and cofilin."Cell. Microbiol. 6:459-471(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Phosphoinositide 3-kinase-mediated activation of cofilin phosphatase Slingshot and its role for insulin-induced membrane protrusion."J. Biol. Chem. 279:7193-7198(2004) [PubMed] [Europe PMC] [Abstract]
  10. "A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia."J. Cell Biol. 165:465-471(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin."EMBO J. 24:473-486(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin."J. Biol. Chem. 280:12683-12689(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration."J. Cell Biol. 171:349-359(2005) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]