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Slingshot Homolog 3 (SSH3)

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SSH3L; SSH-like protein 3; Protein phosphatase Slingshot homolog 3

Slingshot Homolog 3 (SSH3)
CCC J454
HGNC 30581
MGI 2683546
PubMed 21868701
RGD 1308679
UniProt Q8TE77
Wiki SSH3
The ADF (actin-depolymerizing factor)/cofilin family is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo.
Transcript analysis suggested that at least 6 polypeptides would be produced from these genes. SSH1 encodes 3 isoforms, SSH1L, SSH1S, and SSH1B, and SSH2 encodes 2 isoforms, SSH2 and SSH2B. The SSH3 protein has 471 amino acids. Besides the catalytic domain, 2 other domains are conserved between Drosophila ssh and the human SSHs (domains A and B) and are unique to the SSH family.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ454Hu01 Recombinant Slingshot Homolog 3 (SSH3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAJ454Hu21 Monoclonal Antibody to Slingshot Homolog 3 (SSH3) WB; IHC; ICC; IP.
PAJ454Hu01 Polyclonal Antibody to Slingshot Homolog 3 (SSH3) WB; IHC; ICC; IP.
Assay Kits SEJ454Hu ELISA Kit for Slingshot Homolog 3 (SSH3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Slingshot Homolog 3 (SSH3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Slingshot Homolog 3 (SSH3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Slingshot Homolog 3 (SSH3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Slingshot Homolog 3 (SSH3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Slingshot Homolog 3 (SSH3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Slingshot Homolog 3 (SSH3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Slingshot Homolog 3 (SSH3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Slingshot Homolog 3 (SSH3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Slingshot Homolog 3 (SSH3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Slingshot Homolog 3 (SSH3) ELISA Kit Customized Service Offer
  1. "Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin."Cell 108:233-246(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin."Genes Cells 8:811-824(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]