≡

CDC Like Kinase 4 (CLK4)

[Edit]

Dual specificity protein kinase CLK4

CDC Like Kinase 4 (CLK4)
CCC J444
HGNC 13659
MGI 1098551
PubMed 23496085
UniProt Q9HAZ1
CLK4 belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing.
The deduced 481-amino acid protein has a calculated molecular mass of about 54 kD. CLK4 shares 97% identity with murine Clk4. Northern blot analysis detected 4 transcripts that ranged from about 2.0 to 4.5 kb. Strongest expression was in liver, kidney, heart, skeletal muscle, and brain. All 4 transcripts were expressed evenly in kidney and liver, while the 2.8-kb transcript predominated in heart and skeletal muscle. Analysis of a multiple tissue expression array showed CLK4 expression in all samples tested.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CDC Like Kinase 4 (CLK4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CDC Like Kinase 4 (CLK4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CDC Like Kinase 4 (CLK4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CDC Like Kinase 4 (CLK4) CLIA Kit Customized Service Offer
n/a ELISA Kit for CDC Like Kinase 4 (CLK4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CDC Like Kinase 4 (CLK4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CDC Like Kinase 4 (CLK4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CDC Like Kinase 4 (CLK4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CDC Like Kinase 4 (CLK4) CLIA Kit Customized Service Offer
n/a ELISA Kit for CDC Like Kinase 4 (CLK4) ELISA Kit Customized Service Offer
  1. "Molecular characterization of a cDNA encoding functional human CLK4 kinase and localization to chromosome 5q35."Genomics 71:368-370(2001) [PubMed] [Europe PMC] [Abstract]
  2. ErratumGenomics 74:251-251(2001)
  3. "Structural analysis of UBL5, a novel ubiquitin-like modifier."Protein Sci. 12:1562-1566(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Beacon interacts with cdc2/cdc28-like kinases."Biochem. Biophys. Res. Commun. 304:125-129(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells."Circ. Res. 104:589-599(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]