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Dynamin Binding Protein (DNMBP)

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Tuba; ARHGEF36; Scaffold Protein TUBA

Dynamin Binding Protein (DNMBP)
CCC J426
HGNC 30373
MGI 1917352
PubMed 16740596
RGD 1583840
UniProt Q6XZF7
DNMBP belongs to the DBL family of guanine nucleotide exchange factors and plays a role in the regulation of cell junctions. The transcript contains a repetitive element in its 3-prime UTR, and the deduced protein contains motifs suggesting it is a guanine nucleotide regulatory protein. RT-PCR ELISA detected moderate expression in ovary, testis, liver, and lung and low expression in all other tissues examined. Expression was low in all specific brain regions examined and moderate in spinal cord.The deduced 1,577-amino acid protein has a calculated molecular mass of 178 kD. It has 4 N-terminal SH3 domains, followed by a proline-rich region, a coiled-coil domain, a DBL homology (DH) domain, a BIN / amphiphysin /Rvs (BAR) domain, and 2 C-terminal SH3 domains.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dynamin Binding Protein (DNMBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dynamin Binding Protein (DNMBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dynamin Binding Protein (DNMBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dynamin Binding Protein (DNMBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dynamin Binding Protein (DNMBP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dynamin Binding Protein (DNMBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dynamin Binding Protein (DNMBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dynamin Binding Protein (DNMBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dynamin Binding Protein (DNMBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dynamin Binding Protein (DNMBP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dynamin Binding Protein (DNMBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dynamin Binding Protein (DNMBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dynamin Binding Protein (DNMBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dynamin Binding Protein (DNMBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dynamin Binding Protein (DNMBP) ELISA Kit Customized Service Offer
  1. "Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton."J. Biol. Chem. 278:49031-49043(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "NMR structure of SH3 domain of hypothetical protein BAA76854.1."Submitted (DEC-2003) to the PDB data bank