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Deoxynucleotidyltransferase Terminal Interacting Protein 2 (DNTTIP2)

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ERBP; FCF2; TdIF2; Acidic 82 kDa Protein mRNA; Estrogen receptor-binding protein; LPTS-interacting protein 2; Terminal deoxynucleotidyltransferase-interacting factor 2

Deoxynucleotidyltransferase Terminal Interacting Protein 2 (DNTTIP2)
CCC J423
HGNC 24013
MGI 1923173
PubMed 15047147
UniProt Q5QJE6
Wiki DNTTIP2
ERBP C-terminal and N-terminal fragments interacted with the DNA binding domain and hinge region of ER-alpha. Binding of the C-terminal ERBP fragment was enhanced in the presence of estrogen. ERBP also bound ER-beta (ESR2), but this interaction was not affected by estrogen. Overexpression of ERBP enhanced ER-alpha-mediated transactivation in an estrogen-dependent manner. Transcriptional activity assay showed that ERBP itself lacked intrinsic transcription activity.
The deduced 756-amino acid protein has a calculated molecular mass of approximately 82 kD. ERBP localized to the nucleus in HeLa cells and in transfected COS-7 cells. Northern blot analysis detected expression of a 2.4-kb transcript in all tissues examined, with high levels in testis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Deoxynucleotidyltransferase Terminal Interacting Protein 2 (DNTTIP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Deoxynucleotidyltransferase Terminal Interacting Protein 2 (DNTTIP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Deoxynucleotidyltransferase Terminal Interacting Protein 2 (DNTTIP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Deoxynucleotidyltransferase Terminal Interacting Protein 2 (DNTTIP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Deoxynucleotidyltransferase Terminal Interacting Protein 2 (DNTTIP2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Deoxynucleotidyltransferase Terminal Interacting Protein 2 (DNTTIP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Deoxynucleotidyltransferase Terminal Interacting Protein 2 (DNTTIP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Deoxynucleotidyltransferase Terminal Interacting Protein 2 (DNTTIP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Deoxynucleotidyltransferase Terminal Interacting Protein 2 (DNTTIP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Deoxynucleotidyltransferase Terminal Interacting Protein 2 (DNTTIP2) ELISA Kit Customized Service Offer
  1. "Terminal deoxynucleotidyltransferase forms a ternary complex with a novel chromatin remodeling protein with 82 kDa and core histone."Genes Cells 8:559-571(2003) [PubMed] [Europe PMC] [Abstract]
  2. "ERBP, a novel estrogen receptor binding protein enhancing the activity of estrogen receptor."Biochem. Biophys. Res. Commun. 317:54-59(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]