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Calponin 1, Basic (CNN1)

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SMCC; Sm-Calp; Smooth Muscle Cell Calponin

Calponin 1, Basic (CNN1)
CCC J419
HGNC 2155
MGI 104979
RGD 621883
UniProt P51911
Calponin is a basic 34-kD protein first isolated from chicken gizzard and bovine aorta. It is specifically expressed in smooth muscle and binds calmodulin, actin, and tropomyosin. It is able to inhibit the ATPase activity of myosin and is thought to play a role in smooth muscle contraction. These are the products of separate loci. Northern blots of mouse uterus RNA indicated that h1 transcripts are about 10-fold higher than those of the h2 gene.
The 297-amino acid CNN1 contains a motif that is tandemly repeated 3 times. The N terminus of CNN1 is markedly basic and highly homologous to that of CNN3. CNN1 has a predicted pI of 9.4. Northern blot analysis of RNA from human tissues showed that CNN1 is specifically expressed in smooth muscle.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ419Hu01 Recombinant Calponin 1, Basic (CNN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ419Hu01 Polyclonal Antibody to Calponin 1, Basic (CNN1) WB; IHC; ICC; IP.
MAJ419Hu21 Monoclonal Antibody to Calponin 1, Basic (CNN1) WB; IHC; ICC; IP.
Assay Kits SEJ419Hu ELISA Kit for Calponin 1, Basic (CNN1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calponin 1, Basic (CNN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calponin 1, Basic (CNN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calponin 1, Basic (CNN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calponin 1, Basic (CNN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calponin 1, Basic (CNN1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calponin 1, Basic (CNN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calponin 1, Basic (CNN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calponin 1, Basic (CNN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calponin 1, Basic (CNN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calponin 1, Basic (CNN1) ELISA Kit Customized Service Offer
  1. "Molecular cloning and gene mapping of human basic and acidic calponins."Biochem. Biophys. Res. Commun. 217:238-244(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Expression, genomic structure and high resolution mapping to 19p13.2 of the human smooth muscle cell calponin gene."Gene 197:215-224(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Solution structure of the CH domain of human calponin 1."Submitted (AUG-2005) to the PDB data bank