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Biogenesis Of Lysosomal Organelles Complex 1, Subunit 4 (BLOC1S4)

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BCAS4L; CNO; Cappuccino Homolog

Biogenesis Of Lysosomal Organelles Complex 1, Subunit 4 (BLOC1S4)
CCC J408
HGNC 24206
MGI 1929230
PubMed 17923532
RGD 1306037
UniProt Q9NUP1
Wiki CNO
This intronless gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. A similar protein in mouse is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 (BLOC-1), and is a model for Hermansky-Pudlak syndrome. The encoded protein may play a role in intracellular vesicular trafficking.
The mouse and human proteins share 77% overall sequence identity. There are no predicted transmembrane domains, suggesting that the protein is cytosolic. Northern blot analysis detected ubiquitous expression of an approximately 1.35-kb CNO transcript. An additional, high molecular mass band was detected in skeletal muscle.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Biogenesis Of Lysosomal Organelles Complex 1, Subunit 4 (BLOC1S4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Biogenesis Of Lysosomal Organelles Complex 1, Subunit 4 (BLOC1S4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Biogenesis Of Lysosomal Organelles Complex 1, Subunit 4 (BLOC1S4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Biogenesis Of Lysosomal Organelles Complex 1, Subunit 4 (BLOC1S4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Biogenesis Of Lysosomal Organelles Complex 1, Subunit 4 (BLOC1S4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Biogenesis Of Lysosomal Organelles Complex 1, Subunit 4 (BLOC1S4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Biogenesis Of Lysosomal Organelles Complex 1, Subunit 4 (BLOC1S4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Biogenesis Of Lysosomal Organelles Complex 1, Subunit 4 (BLOC1S4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Biogenesis Of Lysosomal Organelles Complex 1, Subunit 4 (BLOC1S4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Biogenesis Of Lysosomal Organelles Complex 1, Subunit 4 (BLOC1S4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Biogenesis Of Lysosomal Organelles Complex 1, Subunit 4 (BLOC1S4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Biogenesis Of Lysosomal Organelles Complex 1, Subunit 4 (BLOC1S4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Biogenesis Of Lysosomal Organelles Complex 1, Subunit 4 (BLOC1S4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Biogenesis Of Lysosomal Organelles Complex 1, Subunit 4 (BLOC1S4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Biogenesis Of Lysosomal Organelles Complex 1, Subunit 4 (BLOC1S4) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles."Mol. Biol. Cell 18:768-780(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Assembly and architecture of biogenesis of lysosome-related organelles complex-1 (BLOC-1)."J. Biol. Chem. 287:5882-5890(2012) [PubMed] [Europe PMC] [Abstract]