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Centrobin (CNTROB)

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LIP8; Centrosomal BRCA2 Interacting Protein; LYST-interacting protein 8

Centrobin (CNTROB)
CCC J407
HGNC 29616
MGI 2443290
PubMed 16275750
RGD 1307488
UniProt Q8N137
CNTROB is a centrosomal protein that interacts with BRCA2 and is required for centriole duplication and cytokinesis.The authors identified transcripts encoding a deduced 903-amino acid predominant isoform called centrobin-alpha and a deduced 925-amino acid minor isoform, centrobin-beta. CNTROB contains a predicted central coiled-coil region with N- and C-terminal noncoiled regions, a structure common to centrosomal proteins pericentrin (PCNT1) and ninein (NIN). Immunofluorescence studies using the normal mammary epithelial cell line 76N and several cancer cell lines localized CNTROB to 1 or 2 perinuclear dots in interphase cells and to a single focus at the end of each mitotic spindle in mitotic cells, in a pattern colocalizing with that of centrosomal protein gamma-tubulin (TUBG1).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centrobin (CNTROB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centrobin (CNTROB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centrobin (CNTROB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centrobin (CNTROB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centrobin (CNTROB) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centrobin (CNTROB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centrobin (CNTROB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centrobin (CNTROB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centrobin (CNTROB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centrobin (CNTROB) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centrobin (CNTROB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centrobin (CNTROB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centrobin (CNTROB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centrobin (CNTROB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centrobin (CNTROB) ELISA Kit Customized Service Offer
  1. "Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication."J. Cell Biol. 171:437-445(2005) [PubMed] [Europe PMC] [Abstract]
  2. "Large-scale cDNA transfection screening for genes related to cancer development and progression." Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins."Mol. Med. 8:56-64(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]