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Carbohydrate Sulfotransferase 8 (CHST8)

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GALNAC-4-ST1; N-acetylgalactosamine-4-O-sulfotransferase 1; GalNAc-4-O-sulfotransferase 1

Carbohydrate Sulfotransferase 8 (CHST8)
CCC J398
HGNC 15993
MGI 1916197
PubMed 21982770
RGD 1308979
UniProt Q9H2A9
Sulfate groups in carbohydrates confer highly specific functions on glycoproteins, glycolipids, and proteoglycans and are critical for cell-cell interaction, signal transduction, and embryonic development. Sulfotransferases, such as CHST8, carry out sulfation of carbohydrates.
The deduced 424-amino acid protein has a calculated molecular mass of 48.8 kD. It has an N-terminal transmembrane domain, followed by putative 5-prime-phosphosulfonate- and 3-prime-phosphate-binding sites and 3 additional regions conserved in other sulfotransferases. GalNAc4ST1 has 4 potential N-glycosylation sites.GalNAc4ST1 transferred sulfate to C4 of GalNAc in the context of GalNAc-beta-1,4-GlcNAc-beta-1-R in both N- and O-glycans; products were monosulfated.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carbohydrate Sulfotransferase 8 (CHST8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carbohydrate Sulfotransferase 8 (CHST8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carbohydrate Sulfotransferase 8 (CHST8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carbohydrate Sulfotransferase 8 (CHST8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbohydrate Sulfotransferase 8 (CHST8) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carbohydrate Sulfotransferase 8 (CHST8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carbohydrate Sulfotransferase 8 (CHST8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carbohydrate Sulfotransferase 8 (CHST8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carbohydrate Sulfotransferase 8 (CHST8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbohydrate Sulfotransferase 8 (CHST8) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carbohydrate Sulfotransferase 8 (CHST8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carbohydrate Sulfotransferase 8 (CHST8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carbohydrate Sulfotransferase 8 (CHST8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carbohydrate Sulfotransferase 8 (CHST8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbohydrate Sulfotransferase 8 (CHST8) ELISA Kit Customized Service Offer
  1. "Molecular cloning and expression of the pituitary glycoprotein hormone N-acetylgalactosamine-4-O-sulfotransferase."J. Biol. Chem. 275:38402-38409(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and characterization of GalNAc 4-sulfotransferase expressed in human pituitary gland."J. Biol. Chem. 275:40605-40613(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning and expression of two distinct human N-acetylgalactosamine 4-O-sulfotransferases that transfer sulfate to GalNAc beta 1->4GlcNAc beta 1->R in both N- and O-glycans."Glycobiology 11:495-504(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Glycosylation-related gene expression in prion diseases: PrPSc accumulation in scrapie infected GT1 cells depends on beta-1,4-linked GalNAc-4-SO4 hyposulfation."J. Biol. Chem. 280:10516-10523(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Whole-exome sequencing in a single proband reveals a mutation in the CHST8 gene in autosomal recessive peeling skin syndrome."Genomics 99:202-208(2012) [PubMed] [Europe PMC] [Abstract]
  7. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]