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Carbohydrate Sulfotransferase 15 (CHST15)

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BRAG; GALNAC4S-6ST; B Cell RAG Associated Protein; N-Acetylgalactosamine 4-Sulfate 6-O-Sulfotransferase

Carbohydrate Sulfotransferase 15 (CHST15)
CCC J394
HGNC 18137
MGI 1924840
RGD 628881
UniProt Q7LFX5
CHST15 contains 503 amino acids and has a calculated molecular mass of 55 kD. In vitro translation resulted in a doublet that migrated between 69 and 49 kD by SDS-PAGE. BRAG is a type II transmembrane glycoprotein with an 81-amino acid cytoplasmic N terminus, followed by a transmembrane domain, and a 405-amino acid extracellular C terminus. The N terminus contains a putative palmitoylation site and several phosphorylation sites, and the C terminus contains 4 putative N-glycosylation sites.
BRAG transcript expressed in all B-cell lines that also expressed RAG1. Little or no expression was detected in several nonlymphoid cell lines, and no expression was detected in T-cell lines, irrespective of RAG1 expression.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carbohydrate Sulfotransferase 15 (CHST15) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carbohydrate Sulfotransferase 15 (CHST15) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carbohydrate Sulfotransferase 15 (CHST15) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carbohydrate Sulfotransferase 15 (CHST15) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbohydrate Sulfotransferase 15 (CHST15) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carbohydrate Sulfotransferase 15 (CHST15) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carbohydrate Sulfotransferase 15 (CHST15) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carbohydrate Sulfotransferase 15 (CHST15) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carbohydrate Sulfotransferase 15 (CHST15) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbohydrate Sulfotransferase 15 (CHST15) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carbohydrate Sulfotransferase 15 (CHST15) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carbohydrate Sulfotransferase 15 (CHST15) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carbohydrate Sulfotransferase 15 (CHST15) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carbohydrate Sulfotransferase 15 (CHST15) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbohydrate Sulfotransferase 15 (CHST15) ELISA Kit Customized Service Offer
  1. "hBRAG, a novel B cell lineage cDNA encoding a type II transmembrane glycoprotein potentially involved in the regulation of recombination activating gene 1 (RAG1)."Eur. J. Immunol. 28:2839-2853(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Structure, expression and mutational analysis of the hBRAG gene on 10q in the frequently deleted region in human endometrial cancer."Oncol. Rep. 7:1339-1342(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Human N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase cDNA is related to human B cell recombination activating gene-associated gene."J. Biol. Chem. 276:43894-43900(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Characterization of the human B cell RAG-associated gene, hBRAG, as a B cell receptor signal-enhancing glycoprotein dimer that associates with phosphorylated proteins in resting B cells."J. Biol. Chem. 275:20967-20979(2000) [PubMed] [Europe PMC] [Abstract]
  9. "A unique nonreducing terminal modification of chondroitin sulfate by N-acetylgalactosamine 4-sulfate 6-o-sulfotransferase."J. Biol. Chem. 278:38443-38452(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Synthesis of sulfated phenyl 2-acetamido-2-deoxy-D--D-galactopyranosides. 4-O-Sulfated phenyl 2-acetamido-2-deoxy-beta-D-galactopyranoside is a competitive acceptor that decreases sulfation of chondroitin sulfate by N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase."Carbohydr. Res. 340:1983-1996(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]