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Chromatin Modifying Protein 6 (CHMP6)

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VPS20; Charged Multivesicular Body Protein 6; Vacuolar protein sorting-associated protein 20

Chromatin Modifying Protein 6 (CHMP6)
CCC J379
HGNC 25675
MGI 3583942
PubMed 11559748
RGD 1565325
UniProt Q96FZ7
Wiki CHMP6
CHMP6 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III, a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A , is required for both MVB formation and regulation of cell cycle progression.
The deduced 201-amino acid protein contains 2 coiled-coil domains, an N-myristoylation site, and clusters of basic and acidic residues in its N- and C-terminal regions, respectively. Metabolic labeling confirmed that CHMP6 is myristoylated. Fluorescence-tagged CHMP6 localized in a punctate distribution in HeLa cells, mostly in the perinuclear area. .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromatin Modifying Protein 6 (CHMP6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromatin Modifying Protein 6 (CHMP6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromatin Modifying Protein 6 (CHMP6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromatin Modifying Protein 6 (CHMP6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromatin Modifying Protein 6 (CHMP6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromatin Modifying Protein 6 (CHMP6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromatin Modifying Protein 6 (CHMP6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromatin Modifying Protein 6 (CHMP6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromatin Modifying Protein 6 (CHMP6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromatin Modifying Protein 6 (CHMP6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromatin Modifying Protein 6 (CHMP6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromatin Modifying Protein 6 (CHMP6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromatin Modifying Protein 6 (CHMP6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromatin Modifying Protein 6 (CHMP6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromatin Modifying Protein 6 (CHMP6) ELISA Kit Customized Service Offer
  1. "Structure and function of human Vps20 and Snf7 proteins."Biochem. J. 377:693-700(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The protein network of HIV budding."Cell 114:701-713(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins."Proc. Natl. Acad. Sci. U.S.A. 100:12414-12419(2003) [PubMed] [Europe PMC] [Abstract]
  6. ErratumProc. Natl. Acad. Sci. U.S.A. 100:152845-152845(2003)
  7. "Human CHMP6, a myristoylated ESCRT-III protein, interacts directly with an ESCRT-II component EAP20 and regulates endosomal cargo sorting."Biochem. J. 387:17-26(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Structure/function analysis of four core ESCRT-III proteins reveals common regulatory role for extreme C-terminal domain."Traffic 8:1068-1079(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Mechanism of inhibition of retrovirus release from cells by interferon-induced gene ISG15."J. Virol. 85:7153-7161(2011) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "Two distinct modes of ESCRT-III recognition are required for VPS4 functions in lysosomal protein targeting and HIV-1 budding."Dev. Cell 15:62-73(2008) [PubMed] [Europe PMC] [Abstract]