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Coronin 1A (CORO1A)

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CLABP; p57; CLIPINA; HCORO1; TACO; Coronin-1; Coronin,Actin-Binding Protein,1A; Coronin-like protein A; Coronin-like protein p57; Tryptophan aspartate-containing coat protein

Coronin 1A (CORO1A)
CCC J355
HGNC 2252
MGI 1345961
PubMed 9778037
RGD 620009
UniProt P31146
Wiki CORO1A
The deduced 461-amino acid CORO1A protein shares 40% amino acid identity with coronin, an actin-binding protein of Dictyostelium discoideum. Sequence analysis predicted that CORO1A contains a WD (trp/asp) repeat and a leucine zipper motif. Immunoblot analysis revealed cross-reactivity of human, calf, and mouse CORO1A, and Coro1a was clearly expressed in mouse brain, thymus, spleen, bone marrow, and lymph node, with weak expression in lung and gut, and no expression in liver, kidney, stomach, and skeletal muscle.
CORO1A suppressed Toll-like receptor (TLR) signaling following expression in a human monocytic cell line. TLR2-mediated activation of the innate immune response resulted in suppression of CORO1A expression.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ355Hu01 Recombinant Coronin 1A (CORO1A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ355Hu01 Polyclonal Antibody to Coronin 1A (CORO1A) WB; IHC; ICC; IP.
MAJ355Hu21 Monoclonal Antibody to Coronin 1A (CORO1A) WB; IHC; ICC; IP.
Assay Kits SEJ355Hu ELISA Kit for Coronin 1A (CORO1A) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coronin 1A (CORO1A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coronin 1A (CORO1A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coronin 1A (CORO1A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coronin 1A (CORO1A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coronin 1A (CORO1A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ355Ra01 Recombinant Coronin 1A (CORO1A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ355Ra01 Polyclonal Antibody to Coronin 1A (CORO1A) WB; IHC; ICC; IP.
MAJ355Ra21 Monoclonal Antibody to Coronin 1A (CORO1A) WB; IHC; ICC; IP.
Assay Kits SEJ355Ra ELISA Kit for Coronin 1A (CORO1A) Enzyme-linked immunosorbent assay for Antigen Detection.
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  12. "Constitutive turnover of phosphorylation at Thr-412 of human p57/coronin-1 regulates the interaction with actin."J. Biol. Chem. 287:42910-42920(2012) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Whole-exome sequencing identifies Coronin-1A deficiency in 3 siblings with immunodeficiency and EBV-associated B-cell lymphoproliferation."J. Allergy Clin. Immunol. 131:1594-1603(2013) [PubMed] [Europe PMC] [Abstract]