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Cleavage And Polyadenylation Specific Factor 1 (CPSF1)

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CPSF160; Cleavage and polyadenylation specificity factor 160 kDa subunit

Cleavage And Polyadenylation Specific Factor 1 (CPSF1)
CCC J348
HGNC 2324
MGI 2679722
PubMed 23151878
RGD 1306406
UniProt Q10570
Wiki CPSF1
Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex.
The 1,442-amino acid protein contains a bipartite nuclear localization signal and an RNA-binding domain. Northern blot analysis revealed expression of a 5.0-kb transcript. Immunofluorescence microscopy and Western blot analysis showed expression of an exclusively nuclear 160-kD protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ348Hu01 Recombinant Cleavage And Polyadenylation Specific Factor 1 (CPSF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ348Hu01 Polyclonal Antibody to Cleavage And Polyadenylation Specific Factor 1 (CPSF1) WB
MAJ348Hu21 Monoclonal Antibody to Cleavage And Polyadenylation Specific Factor 1 (CPSF1) WB; IHC; ICC; IP.
Assay Kits SEJ348Hu ELISA Kit for Cleavage And Polyadenylation Specific Factor 1 (CPSF1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cleavage And Polyadenylation Specific Factor 1 (CPSF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cleavage And Polyadenylation Specific Factor 1 (CPSF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cleavage And Polyadenylation Specific Factor 1 (CPSF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cleavage And Polyadenylation Specific Factor 1 (CPSF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cleavage And Polyadenylation Specific Factor 1 (CPSF1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cleavage And Polyadenylation Specific Factor 1 (CPSF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cleavage And Polyadenylation Specific Factor 1 (CPSF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cleavage And Polyadenylation Specific Factor 1 (CPSF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cleavage And Polyadenylation Specific Factor 1 (CPSF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cleavage And Polyadenylation Specific Factor 1 (CPSF1) ELISA Kit Customized Service Offer
  1. "The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation."Genes Dev. 9:2672-2683(1995) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "SRm160 splicing coactivator promotes transcript 3'-end cleavage."Mol. Cell. Biol. 22:148-160(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase."EMBO J. 23:616-626(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  7. "The poly A polymerase Star-PAP controls 3'-end cleavage by promoting CPSF interaction and specificity toward the pre-mRNA."EMBO J. 29:4132-4145(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]