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Cartilage Associated Protein (CRTAP)

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CASP; LEPREL3; Leprecan-Like 3

Cartilage Associated Protein (CRTAP)
CCC J337
HGNC 2379
MGI 1891221
PubMed 18566967
RGD 1565180
UniProt O75718
Wiki CRTAP
CRTAP is similar to the chicken and mouse CRTAP genes. The encoded protein is a scaffolding protein that may influence the activity of at least one member of the cytohesin/ARNO family in response to specific cellular stimuli.
Crtap is highly expressed in mouse growth plate proliferating chondrocytes and in cells at the chondroosseous junction. At embryonic day 15.5, it is expressed strongly in the presumptive bone collar of the diaphyses, where vascular and osteoblast invasion is initiated. Its expression is low in hypertrophic chondrocytes, and RT-PCR analysis confirmed expression in both osteoclasts and osteoblasts. Most of the Crtap protein is located within cells, although some signal was detected in the extracellular matrix.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ337Hu01 Recombinant Cartilage Associated Protein (CRTAP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ337Hu01 Polyclonal Antibody to Cartilage Associated Protein (CRTAP) WB; IHC; ICC; IP.
MAJ337Hu21 Monoclonal Antibody to Cartilage Associated Protein (CRTAP) WB; IHC; ICC; IP.
Assay Kits SEJ337Hu ELISA Kit for Cartilage Associated Protein (CRTAP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ337Mu01 Recombinant Cartilage Associated Protein (CRTAP) Positive Control; Immunogen; SDS-PAGE; WB.
RPJ337Mu02 Recombinant Cartilage Associated Protein (CRTAP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ337Mu01 Polyclonal Antibody to Cartilage Associated Protein (CRTAP) WB; IHC; ICC; IP.
PAJ337Mu02 Polyclonal Antibody to Cartilage Associated Protein (CRTAP) WB; IHC; ICC; IP.
Assay Kits SEJ337Mu ELISA Kit for Cartilage Associated Protein (CRTAP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cartilage Associated Protein (CRTAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cartilage Associated Protein (CRTAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cartilage Associated Protein (CRTAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cartilage Associated Protein (CRTAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cartilage Associated Protein (CRTAP) ELISA Kit Customized Service Offer
  1. "cDNA cloning, characterization and chromosome mapping of the gene encoding human cartilage associated protein (CRTAP)."Cytogenet. Cell Genet. 87:191-194(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "CRTAP is required for prolyl 3-hydroxylation and mutations cause recessive osteogenesis imperfecta."Cell 127:291-304(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Deficiency of CRTAP in non-lethal recessive osteogenesis imperfecta reduces collagen deposition into matrix."Clin. Genet. 82:453-459(2012) [PubMed] [Europe PMC] [Abstract]
  7. "CRTAP and LEPRE1 mutations in recessive osteogenesis imperfecta." Hum. Mutat. 29:1435-1442(2008) [PubMed] [Europe PMC] [Abstract]
  8. "CRTAP mutations in lethal and severe osteogenesis imperfecta: the importance of combining biochemical and molecular genetic analysis."Eur. J. Hum. Genet. 17:1560-1569(2009) [PubMed] [Europe PMC] [Abstract]