![Centrosome And Spindle Pole Associated Protein 1 (CSPP1)](/upload/item/img/Centrosome-And-Spindle-Pole-Associated-Protein-1-(CSPP1)-98335.jpg)
CSPP1 interacts with centrosomes and microtubules and plays a role in cell-cycle progression and spindle organization . The deduced 876-amino acid protein is highly charged and has a calculated molecular mass of 101.5 kD. CSPP1 has an N-terminal bipartite nuclear localization signal, a proline-rich region, a central domain consisting of 3 coiled-coil regions, and a C-terminal domain. Immunofluorescence studies localized CSPP1-S along microtubules, accumulating mainly around the centrosome in transfected interphase HEK293T cells. Northern blot analysis of human tissues detected a 4.4-kb transcript in testis.Immunofluorescence studies localized CSPP1-L to the microtubules and centrosomes, accumulating at the microtubule organization center in interphase, similar to CSPP1-S.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Centrosome And Spindle Pole Associated Protein 1 (CSPP1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Centrosome And Spindle Pole Associated Protein 1 (CSPP1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Centrosome And Spindle Pole Associated Protein 1 (CSPP1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Centrosome And Spindle Pole Associated Protein 1 (CSPP1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Centrosome And Spindle Pole Associated Protein 1 (CSPP1) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Centrosome And Spindle Pole Associated Protein 1 (CSPP1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Centrosome And Spindle Pole Associated Protein 1 (CSPP1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Centrosome And Spindle Pole Associated Protein 1 (CSPP1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Centrosome And Spindle Pole Associated Protein 1 (CSPP1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Centrosome And Spindle Pole Associated Protein 1 (CSPP1) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Centrosome And Spindle Pole Associated Protein 1 (CSPP1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Centrosome And Spindle Pole Associated Protein 1 (CSPP1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Centrosome And Spindle Pole Associated Protein 1 (CSPP1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Centrosome And Spindle Pole Associated Protein 1 (CSPP1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Centrosome And Spindle Pole Associated Protein 1 (CSPP1) | ELISA Kit Customized Service Offer |
- "Identification of a novel centrosome/microtubule-associated coiled-coil protein involved in cell-cycle progression and spindle organization."Oncogene 24:1159-1173(2005) [PubMed] [Europe PMC] [Abstract]
- "CSPP and CSPP-L associate with centrosomes and microtubules and differently affect microtubule organization."J. Cell. Physiol. 209:199-210(2006) [PubMed] [Europe PMC] [Abstract]
- "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
- "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
- "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
- "Mutations in CSPP1 cause primary cilia abnormalities and Joubert syndrome with or without Jeune asphyxiating thoracic dystrophy." Am. J. Hum. Genet. 94:62-72(2014) [PubMed] [Europe PMC] [Abstract]
- "Mutations in CSPP1, encoding a core centrosomal protein, cause a range of ciliopathy phenotypes in humans." Am. J. Hum. Genet. 94:73-79(2014) [PubMed] [Europe PMC] [Abstract]
- "Mutations in CSPP1 lead to classical Joubert syndrome." Am. J. Hum. Genet. 94:80-86(2014) [PubMed] [Europe PMC] [Abstract]