≡

dCMP Deaminase (DCTD)

[Edit]

Deoxycytidylate deaminase

dCMP Deaminase (DCTD)
CCC J287
HGNC 2710
MGI 2444529
PubMed 16551864
RGD 1359671
UniProt P32321
Wiki DCTD
DCTD catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene.
The deduced 178-amino acid protein has a calculated molecular mass of about 20 kD and contains a zinc-binding region similar to that in cytidine deaminase. Northern blot analysis revealed a single transcript of 1.9 kb expressed in HeLa cells.DCTD exhibited dCMP deaminase activity comparable to that of the endogenous enzyme purified from HeLa cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant dCMP Deaminase (DCTD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to dCMP Deaminase (DCTD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to dCMP Deaminase (DCTD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for dCMP Deaminase (DCTD) CLIA Kit Customized Service Offer
n/a ELISA Kit for dCMP Deaminase (DCTD) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant dCMP Deaminase (DCTD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to dCMP Deaminase (DCTD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to dCMP Deaminase (DCTD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for dCMP Deaminase (DCTD) CLIA Kit Customized Service Offer
n/a ELISA Kit for dCMP Deaminase (DCTD) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant dCMP Deaminase (DCTD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to dCMP Deaminase (DCTD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to dCMP Deaminase (DCTD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for dCMP Deaminase (DCTD) CLIA Kit Customized Service Offer
n/a ELISA Kit for dCMP Deaminase (DCTD) ELISA Kit Customized Service Offer
  1. "Primary structure of human deoxycytidylate deaminase and overexpression of its functional protein in Escherichia coli."J. Biol. Chem. 268:12983-12989(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Chromosomal location and structural organization of the human deoxycytidylate deaminase gene."J. Biol. Chem. 270:18727-18729(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  8. "The crystal structure of human dCMP deaminase."Submitted (NOV-2008) to the PDB data bank