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DNA Damage Inducible Transcript 3 (DDIT3)

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CEBPZ; CHOP; CHOP10; GADD153; C/EBP-homologous protein 10; CCAAT/enhancer-binding protein homologous protein; Growth arrest and DNA damage-inducible GADD153

DNA Damage Inducible Transcript 3 (DDIT3)
CCC J282
HGNC 2726
MGI 109247
PubMed 14684614
RGD 62391
UniProt P35638
Wiki DDIT3
The DDIT3 gene shows a high level of conservation in both the structural and regulatory regions to the previously described hamster gene. The human and hamster proteins share 91% amino acid identity.CHOP serves as a dominant-negative inhibitor of the transcription factors C/EBP and LAP. bacterially expressed CHOP inhibited the DNA-binding activity of C/EBP and LAP by forming heterodimers that could not bind DNA.Chop also activated Ero1-alpha (ERO1L), which encodes an ER oxidase. Consequently, the ER of stressed Chop -/- cells was hypooxidized relative to the ER of stressed wildtype cells. Pharmacologic and genetic manipulations promoting a hypooxidized ER reduced abnormal high molecular mass protein complexes and protected cells from the lethal consequences of ER stress.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ282Hu01 Recombinant DNA Damage Inducible Transcript 3 (DDIT3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ282Hu01 Polyclonal Antibody to DNA Damage Inducible Transcript 3 (DDIT3) WB; IHC
LAJ282Hu71 Biotin-Linked Polyclonal Antibody to DNA Damage Inducible Transcript 3 (DDIT3) WB; IHC; ICC.
MAJ282Hu21 Monoclonal Antibody to DNA Damage Inducible Transcript 3 (DDIT3) WB; IHC; ICC; IP.
Assay Kits SEJ282Hu ELISA Kit for DNA Damage Inducible Transcript 3 (DDIT3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ282Mu01 Recombinant DNA Damage Inducible Transcript 3 (DDIT3) Positive Control; Immunogen; SDS-PAGE; WB.
RPJ282Mu02 Recombinant DNA Damage Inducible Transcript 3 (DDIT3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ282Mu01 Polyclonal Antibody to DNA Damage Inducible Transcript 3 (DDIT3) WB; IHC; ICC; IP.
PAJ282Mu02 Polyclonal Antibody to DNA Damage Inducible Transcript 3 (DDIT3) WB; IHC; ICC; IP.
Assay Kits SEJ282Mu ELISA Kit for DNA Damage Inducible Transcript 3 (DDIT3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DNA Damage Inducible Transcript 3 (DDIT3) Recombinant Protein Customized Service Offer
Antibodies PAJ282Ra01 Polyclonal Antibody to DNA Damage Inducible Transcript 3 (DDIT3) WB; IHC; ICC; IP.
Assay Kits SEJ282Ra ELISA Kit for DNA Damage Inducible Transcript 3 (DDIT3) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Isolation, characterization and chromosomal localization of the human GADD153 gene."Gene 116:259-267(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma."Nature 363:640-644(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma."Nat. Genet. 4:175-180(1993) [PubMed] [Europe PMC] [Abstract]
  4. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Roles of CHOP/GADD153 in endoplasmic reticulum stress."Cell Death Differ. 11:381-389(2004) [PubMed] [Europe PMC] [Abstract]
  7. "CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells."J. Biol. Chem. 279:45495-45502(2004) [PubMed] [Europe PMC] [Abstract]
  8. "TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death."EMBO J. 24:1243-1255(2005) [PubMed] [Europe PMC] [Abstract]
  9. "The C/EBP homologous protein CHOP (GADD153) is an inhibitor of Wnt/TCF signals."Oncogene 25:3397-3407(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion."J. Biol. Chem. 282:35687-35694(2007) [PubMed] [Europe PMC] [Abstract]
  11. "CHOP transcription factor mediates IL-8 signaling in cystic fibrosis bronchial epithelial cells."Am. J. Respir. Cell Mol. Biol. 38:176-184(2008) [PubMed] [Europe PMC] [Abstract]
  12. "C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene."J. Biol. Chem. 283:35106-35117(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling."Nat. Cell Biol. 11:1473-1480(2009) [PubMed] [Europe PMC] [Abstract]
  14. "ER stress-inducible factor CHOP affects the expression of hepcidin by modulating C/EBPalpha activity."PLoS ONE 4:E6618-E6618(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma."J. Biol. Chem. 285:35330-35339(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression."Proc. Natl. Acad. Sci. U.S.A. 107:17698-17703(2010) [PubMed] [Europe PMC] [Abstract]
  17. "CHOP is a multifunctional transcription factor in the ER stress response."J. Biochem. 151:217-219(2012) [PubMed] [Europe PMC] [Abstract]
  18. "CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress."PLoS ONE 7:E39586-E39586(2012) [PubMed] [Europe PMC] [Abstract]
  19. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]