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Discs, Large Homolog Associated Protein 1 (DLGAP1)

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DAP1; DAP-1-ALPHA; DAP-1-BETA; GKAP; SAPAP1; hGKAP; Guanylate kinase-associated protein; PSD-95/SAP90-binding protein 1; SAP90/PSD-95-associated protein 1

Discs, Large Homolog Associated Protein 1 (DLGAP1)
CCC J259
HGNC 2905
MGI 1346065
PubMed 22940546
RGD 620223
UniProt O14490
Wiki DLGAP1
DLGAP1encodes the protein called guanylate kinase-associated protein (GKAP). GKAP binds to the SHANK and PSD-95 proteins fascilitating the assembly of the post synaptic density of neurons.
Sequence analysis predicted that the 627-amino acid hydrophilic protein, which is 98% identical to the rat sequence, contains five 14-amino acid repeats in its N terminus. Binding analysis determined that the N-terminal region of DLGAP1 interacts with intact GK domains of all members of the DLG family, which share approximately 75% homology in the GK domain; DLGAP1 was found to interact less well with more distantly related MAGUKs. Immunoblot analysis showed expression of 95- and 130-kD DLGAP1 proteins in membranes from different regions of rat brain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Discs, Large Homolog Associated Protein 1 (DLGAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Discs, Large Homolog Associated Protein 1 (DLGAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Discs, Large Homolog Associated Protein 1 (DLGAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Discs, Large Homolog Associated Protein 1 (DLGAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Discs, Large Homolog Associated Protein 1 (DLGAP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Discs, Large Homolog Associated Protein 1 (DLGAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Discs, Large Homolog Associated Protein 1 (DLGAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Discs, Large Homolog Associated Protein 1 (DLGAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Discs, Large Homolog Associated Protein 1 (DLGAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Discs, Large Homolog Associated Protein 1 (DLGAP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Discs, Large Homolog Associated Protein 1 (DLGAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Discs, Large Homolog Associated Protein 1 (DLGAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Discs, Large Homolog Associated Protein 1 (DLGAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Discs, Large Homolog Associated Protein 1 (DLGAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Discs, Large Homolog Associated Protein 1 (DLGAP1) ELISA Kit Customized Service Offer
  1. "DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95."Genes Cells 2:415-424(1997) [PubMed] [Europe PMC] [Abstract]
  2. "GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules."J. Cell Biol. 136:669-678(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 18." Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]