Delta Like Protein 4 (dLL4)

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Hdelta2; Drosophila Delta homolog 4

Delta Like Protein 4 (dLL4)
DLL4 is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain.
The predicted 685-amino acid DLL4 protein exhibits all of the hallmarks of the Delta family of Notch ligands. It has an extracellular region containing 8 EGF-like repeats and a DSL domain involved in Notch binding, as well as a transmembrane domain and a cytoplasmic tail that lacks catalytic motifs. Human DLL4 shares 87% amino acid sequence identity with mouse Dll4. Northern blot analysis of mouse tissues detected highest Dll4 expression in lung, followed by heart, kidney, skeletal muscle, and brain; Dll4 expression was barely detectable in spleen and testis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ256Hu01 Recombinant Delta Like Protein 4 (dLL4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ256Hu01 Polyclonal Antibody to Delta Like Protein 4 (dLL4) WB; IHC; ICC; IP.
MAJ256Hu21 Monoclonal Antibody to Delta Like Protein 4 (dLL4) WB; IHC; ICC; IP.
Assay Kits SEJ256Hu ELISA Kit for Delta Like Protein 4 (dLL4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Delta Like Protein 4 (dLL4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Delta Like Protein 4 (dLL4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Delta Like Protein 4 (dLL4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Delta Like Protein 4 (dLL4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Delta Like Protein 4 (dLL4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ256Ra01 Recombinant Delta Like Protein 4 (dLL4) Positive Control; Immunogen; SDS-PAGE; WB.
RPJ256Ra02 Recombinant Delta Like Protein 4 (dLL4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ256Ra01 Polyclonal Antibody to Delta Like Protein 4 (dLL4) WB; IHC; ICC; IP.
PAJ256Ra02 Polyclonal Antibody to Delta Like Protein 4 (dLL4) WB; IHC; ICC; IP.
LAJ256Ra71 Biotin-Linked Polyclonal Antibody to Delta Like Protein 4 (dLL4) WB; IHC; ICC.
Assay Kits SEJ256Ra ELISA Kit for Delta Like Protein 4 (dLL4) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Dll4, a novel Notch ligand expressed in arterial endothelium."Genes Dev. 14:1313-1318(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning of Delta-4, a new mouse and human Notch ligand."J. Biochem. 129:27-34(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A regulatory network involving Foxn4, Mash1 and delta-like 4/Notch1 generates V2a and V2b spinal interneurons from a common progenitor pool."Development 134:3427-3436(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis."Circ. Res. 107:592-601(2010) [PubMed] [Europe PMC] [Abstract]