Diencephalon/Mesencephalon Homeobox Protein 1 (DMBX1)
[Edit]OTX3; PAXB; Orthodenticle Homolog 3; Paired-like homeobox protein DMBX1
![Diencephalon/Mesencephalon Homeobox Protein 1 (DMBX1)](/upload/item/img/Diencephalon-Mesencephalon-Homeobox-Protein-1-(DMBX1)-98252.jpg)
OTX3 is a homeodomain transcription factor that is structurally and functionally related to OTX1 and OTX2, both of which are critical in brain morphogenesis. The deduced human protein shares approximately 94% sequence identity with the mouse protein. Northern blot analysis of rat tissues detected a single abundant transcript of 4.3 kb only in MIN6 and adult cerebellum. RT-PCR with Otx3-specific primers demonstrated expression in adult pancreatic islets. The Otx3 transcript was detected from 10.5 to 13.5 days postcoitum in mouse embryos, overlapping the temporal expression pattern of Otx1 and Otx2. In situ hybridization studies demonstrated that Otx3 expression is craniocaudally more restricted than that of Otx1 or Otx2, showing the most intense signal at the midbrain-hindbrain boundary.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Diencephalon/Mesencephalon Homeobox Protein 1 (DMBX1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Diencephalon/Mesencephalon Homeobox Protein 1 (DMBX1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Diencephalon/Mesencephalon Homeobox Protein 1 (DMBX1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Diencephalon/Mesencephalon Homeobox Protein 1 (DMBX1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Diencephalon/Mesencephalon Homeobox Protein 1 (DMBX1) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Diencephalon/Mesencephalon Homeobox Protein 1 (DMBX1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Diencephalon/Mesencephalon Homeobox Protein 1 (DMBX1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Diencephalon/Mesencephalon Homeobox Protein 1 (DMBX1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Diencephalon/Mesencephalon Homeobox Protein 1 (DMBX1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Diencephalon/Mesencephalon Homeobox Protein 1 (DMBX1) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Diencephalon/Mesencephalon Homeobox Protein 1 (DMBX1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Diencephalon/Mesencephalon Homeobox Protein 1 (DMBX1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Diencephalon/Mesencephalon Homeobox Protein 1 (DMBX1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Diencephalon/Mesencephalon Homeobox Protein 1 (DMBX1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Diencephalon/Mesencephalon Homeobox Protein 1 (DMBX1) | ELISA Kit Customized Service Offer |
- "The homeobox gene mbx is involved in eye and tectum development."Dev. Biol. 248:107-117(2002) [PubMed] [Europe PMC] [Abstract]
- Ref.1"The homeobox gene mbx is involved in eye and tectum development."Dev. Biol. 248:107-117(2002) [PubMed] [Europe PMC] [Abstract]
- "Identification, tissue expression, and functional characterization of Otx3, a novel member of the Otx family."J. Biol. Chem. 277:28065-28069(2002) [PubMed] [Europe PMC] [Abstract]
- Ref.2"Identification, tissue expression, and functional characterization of Otx3, a novel member of the Otx family."J. Biol. Chem. 277:28065-28069(2002) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
- "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]