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DNA Methyltransferase 3A (DNMT3A)

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DNMT3A2; M.HsaIIIA; DNA methyltransferase HsaIIIA

DNA Methyltransferase 3A (DNMT3A)
CCC J245
HGNC 2978
MGI 1261827
PubMed 22489043
RGD 1303336
UniProt Q9Y6K1
Wiki DNMT3A
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. DNMT3A encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.The mouse genes, termed Dnmt3a and Dnmt3b, show little sequence similarity to mouse Dnmt1 and Dnmt2, and masc1 from Ascobolus. The Dnmt3a cDNA encodes a protein of 908 amino acids. The human DNMT3A and DNMT3B cDNAs are highly homologous to the mouse genes. Dnmt3a and Dnmt3b transcripts were abundantly expressed in undifferentiated embryonic stem cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ245Hu01 Recombinant DNA Methyltransferase 3A (DNMT3A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAJ245Hu21 Monoclonal Antibody to DNA Methyltransferase 3A (DNMT3A) WB; IHC; ICC; IP.
PAJ245Hu01 Polyclonal Antibody to DNA Methyltransferase 3A (DNMT3A) WB; IHC; ICC; IP.
Assay Kits SEJ245Hu ELISA Kit for DNA Methyltransferase 3A (DNMT3A) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DNA Methyltransferase 3A (DNMT3A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DNA Methyltransferase 3A (DNMT3A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DNA Methyltransferase 3A (DNMT3A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DNA Methyltransferase 3A (DNMT3A) CLIA Kit Customized Service Offer
n/a ELISA Kit for DNA Methyltransferase 3A (DNMT3A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DNA Methyltransferase 3A (DNMT3A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DNA Methyltransferase 3A (DNMT3A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DNA Methyltransferase 3A (DNMT3A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DNA Methyltransferase 3A (DNMT3A) CLIA Kit Customized Service Offer
n/a ELISA Kit for DNA Methyltransferase 3A (DNMT3A) ELISA Kit Customized Service Offer
  1. "Cloning, expression and chromosome locations of the human DNMT3 gene family."Gene 236:87-95(1999) [PubMed] [Europe PMC] [Abstract]
  2. "A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation."J. Biol. Chem. 277:38746-38754(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases."EMBO J. 21:4183-4195(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors."Nucleic Acids Res. 27:2291-2298(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The histone methyltransferase SETDB1 and the DNA methyltransferase DNMT3A interact directly and localize to promoters silenced in cancer cells."J. Biol. Chem. 281:19489-19500(2006) [PubMed] [Europe PMC] [Abstract]
  9. "The Polycomb group protein EZH2 directly controls DNA methylation."Nature 439:871-874(2006) [PubMed] [Europe PMC] [Abstract]
  10. ErratumNature 446:824-824(2006)
  11. "Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer."Nat. Genet. 39:232-236(2007) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion."EMBO J. 29:3673-3687(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndrome with intellectual disability." Nat. Genet. 46:385-388(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation."Nature 449:248-251(2007) [PubMed] [Europe PMC] [Abstract]
  18. "Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX-DNMT3-DNMT3L domain."EMBO Rep. 10:1235-1241(2009) [PubMed] [Europe PMC] [Abstract]
  19. "MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a."Nat. Commun. 2:533-533(2011) [PubMed] [Europe PMC] [Abstract]
  20. "Structural and histone binding ability characterizations of human PWWP domains."PLoS ONE 6:E18919-E18919(2011) [PubMed] [Europe PMC] [Abstract]
  21. "Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A."Blood 118:3932-3941(2011) [PubMed] [Europe PMC] [Abstract]