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Dynein, Cytoplasmic 1, Intermediate Chain 2 (DYNC1I2)

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DNCI2; IC2; Dynein intermediate chain 2, cytosolic; Cytoplasmic dynein intermediate chain 2; Cytoplasmic dynein 1 intermediate chain 2

Dynein, Cytoplasmic 1, Intermediate Chain 2 (DYNC1I2)
CCC J212
HGNC 2964
MGI 107750
PubMed 20657784
RGD 620174
UniProt Q13409
Wiki DYNC1I2
Cytoplasmic dynein is a minus end-directed microtubule motor composed of 2 catalytic heavy chains and accessory subunits, including intermediate and light intermediate chains. The 2 Chlamydomonas flagellar dynein intermediate chains (ICs) have been localized to the base of the dynein complex and bind directly to the A-microtubule of the flagellar outer doublet. Based on homology with the Chlamydomonas flagellar dynein ICs, they proposed a role for cytoplasmic dynein ICs in linking the motor protein to organelles and kinetochores. The predicted human and rat IC2 proteins are 94% identical. The predicted protein is 99% and 77% identical to rat Dnci2 and human DNCI1, respectively. Northern blot analysis indicated that Dnci2 was expressed broadly in all mouse tissues tested.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dynein, Cytoplasmic 1, Intermediate Chain 2 (DYNC1I2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dynein, Cytoplasmic 1, Intermediate Chain 2 (DYNC1I2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dynein, Cytoplasmic 1, Intermediate Chain 2 (DYNC1I2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dynein, Cytoplasmic 1, Intermediate Chain 2 (DYNC1I2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dynein, Cytoplasmic 1, Intermediate Chain 2 (DYNC1I2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dynein, Cytoplasmic 1, Intermediate Chain 2 (DYNC1I2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dynein, Cytoplasmic 1, Intermediate Chain 2 (DYNC1I2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dynein, Cytoplasmic 1, Intermediate Chain 2 (DYNC1I2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dynein, Cytoplasmic 1, Intermediate Chain 2 (DYNC1I2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dynein, Cytoplasmic 1, Intermediate Chain 2 (DYNC1I2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dynein, Cytoplasmic 1, Intermediate Chain 2 (DYNC1I2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dynein, Cytoplasmic 1, Intermediate Chain 2 (DYNC1I2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dynein, Cytoplasmic 1, Intermediate Chain 2 (DYNC1I2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dynein, Cytoplasmic 1, Intermediate Chain 2 (DYNC1I2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dynein, Cytoplasmic 1, Intermediate Chain 2 (DYNC1I2) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Cytoplasmic dynein binds dynactin through a direct interaction between the intermediate chains and p150Glued."J. Cell Biol. 131:1507-1516(1995) [PubMed] [Europe PMC] [Abstract]
  6. , Submitted (MAR-2007) to UniProtKB
  7. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Adenovirus transport via direct interaction of cytoplasmic dynein with the viral capsid hexon subunit."Cell Host Microbe 6:523-535(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]