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Dynein, Axonemal, Light Chain 1 (DNAL1)

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C14orf168

Dynein, Axonemal, Light Chain 1 (DNAL1)
CCC J196
HGNC 23247
MGI 1921462
PubMed 15845866
RGD 1591349
UniProt Q4LDG9
Wiki DNAL1
DNAL1 is a component of outer dynein arms, which contain the molecular motors for ATP-dependent cilia movement . DNAL1 gene contains 8 exons and spans 49 kb. The mouse Dnal1 gene contains 8 coding exons and spans 25 kb.
The deduced 190-amino acid protein is 54% identical to Chlamydomonas LC1 and 93% identical to mouse Dnal1. Northern blot analysis detected a 0.9-kb DNAL1 transcript in testis only. In situ hybridization of gastrulation stage mouse embryos detected Dnal1 expression only in the node, where the authors suggested it may contribute to motile 9+0 cilia function. In adult animals, Dnal1 was found in respiratory epithelium of the upper airways and in ependymal cells lining brain ventricles and the aqueduct of Sylvius.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dynein, Axonemal, Light Chain 1 (DNAL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dynein, Axonemal, Light Chain 1 (DNAL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dynein, Axonemal, Light Chain 1 (DNAL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dynein, Axonemal, Light Chain 1 (DNAL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dynein, Axonemal, Light Chain 1 (DNAL1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dynein, Axonemal, Light Chain 1 (DNAL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dynein, Axonemal, Light Chain 1 (DNAL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dynein, Axonemal, Light Chain 1 (DNAL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dynein, Axonemal, Light Chain 1 (DNAL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dynein, Axonemal, Light Chain 1 (DNAL1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dynein, Axonemal, Light Chain 1 (DNAL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dynein, Axonemal, Light Chain 1 (DNAL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dynein, Axonemal, Light Chain 1 (DNAL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dynein, Axonemal, Light Chain 1 (DNAL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dynein, Axonemal, Light Chain 1 (DNAL1) ELISA Kit Customized Service Offer
  1. "Identification and analysis of axonemal dynein light chain 1 in primary ciliary dyskinesia patients."Am. J. Respir. Cell Mol. Biol. 33:41-47(2005) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  7. "Primary ciliary dyskinesia caused by homozygous mutation in DNAL1, encoding dynein light chain 1."Am. J. Hum. Genet. 88:599-607(2011) [PubMed] [Europe PMC] [Abstract]