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E2F Transcription Factor 4 (E2F4)

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E2F Transcription Factor 4 (E2F4)
CCC J184
HGNC 3118
MGI 103012
PubMed 21247883
UniProt Q16254
Wiki E2F4
E2F4 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant E2F Transcription Factor 4 (E2F4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to E2F Transcription Factor 4 (E2F4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to E2F Transcription Factor 4 (E2F4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for E2F Transcription Factor 4 (E2F4) CLIA Kit Customized Service Offer
n/a ELISA Kit for E2F Transcription Factor 4 (E2F4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant E2F Transcription Factor 4 (E2F4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to E2F Transcription Factor 4 (E2F4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to E2F Transcription Factor 4 (E2F4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for E2F Transcription Factor 4 (E2F4) CLIA Kit Customized Service Offer
n/a ELISA Kit for E2F Transcription Factor 4 (E2F4) ELISA Kit Customized Service Offer
  1. "E2F-4, a new member of the E2F transcription factor family, interacts with p107."Genes Dev. 8:2665-2679(1994) [PubMed] [Europe PMC] [Abstract]
  2. "E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo."Genes Dev. 8:2680-2690(1994) [PubMed] [Europe PMC] [Abstract]
  3. "E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle."Proc. Natl. Acad. Sci. U.S.A. 92:2403-2407(1995) [PubMed] [Europe PMC] [Abstract]
  4. "Genomic structure and mutation screening of the E2F4 gene in human tumors."Int. J. Cancer 86:672-677(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
  6. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The predominant E2F complex in human primary haemopoietic cells and in AML blasts contains E2F-4, DP-1 and p130."Br. J. Haematol. 96:688-696(1997) [PubMed] [Europe PMC] [Abstract]
  9. "E2F transcriptional activation requires TRRAP and GCN5 cofactors."J. Biol. Chem. 276:32627-32634(2001) [PubMed] [Europe PMC] [Abstract]
  10. "HCF-1 functions as a coactivator for the zinc finger protein Krox20."J. Biol. Chem. 278:51116-51124(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity."Genes Dev. 18:912-925(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release."Cell 123:1093-1106(2005) [PubMed] [Europe PMC] [Abstract]
  13. "LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes."Cell Cycle 6:1903-1913(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence."Mol. Cell 26:539-551(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence."EMBO J. 31:95-109(2012) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP."Genes Dev. 13:666-674(1999) [PubMed] [Europe PMC] [Abstract]
  19. "Various AGC repeat numbers in the coding region of the human transcription factor gene E2F-4."Hum. Mutat. 15:296-297(2000) [PubMed] [Europe PMC] [Abstract]