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Elongation Factor RNA Polymerase II (ELL)

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C19orf17; Men; ELL1; Eleven-Nineteen Lysine-Rich Leukemia; RNA polymerase II elongation factor ELL

Elongation Factor RNA Polymerase II (ELL)
CCC J171
HGNC 23114
MGI 109377
PubMed 16006523
RGD 1311121
UniProt P55199
Wiki ELL
The sequence of this gene was amplified and used as a probe to screen a fetal brain cDNA library. On Northern blot analysis, this cDNA detected a 4.4-kb transcript that was abundant in peripheral blood leukocytes, skeletal muscle, placenta, and testis and expressed at lower levels in spleen, thymus, heart, brain, lung, kidney, liver, and ovary. In addition, a 2.8-kb transcript was present in peripheral blood, testis, and placenta. On zoo blots, this gene was shown to be evolutionarily conserved in 10 mammalian species, as well as in chicken, frog, and fish. They named the gene ELL (for 'eleven-nineteen lysine-rich leukemia' gene). A highly basic, lysine-rich motif of the predicted ELL protein was homologous to similar regions of several proteins, including the DNA-binding domain of poly(ADP-ribose) polymerase.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Elongation Factor RNA Polymerase II (ELL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Elongation Factor RNA Polymerase II (ELL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Elongation Factor RNA Polymerase II (ELL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Elongation Factor RNA Polymerase II (ELL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Elongation Factor RNA Polymerase II (ELL) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Elongation Factor RNA Polymerase II (ELL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Elongation Factor RNA Polymerase II (ELL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Elongation Factor RNA Polymerase II (ELL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Elongation Factor RNA Polymerase II (ELL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Elongation Factor RNA Polymerase II (ELL) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Elongation Factor RNA Polymerase II (ELL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Elongation Factor RNA Polymerase II (ELL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Elongation Factor RNA Polymerase II (ELL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Elongation Factor RNA Polymerase II (ELL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Elongation Factor RNA Polymerase II (ELL) ELISA Kit Customized Service Offer
  1. "Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia."Proc. Natl. Acad. Sci. U.S.A. 91:12110-12114(1994) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "An RNA polymerase II elongation factor encoded by the human ELL gene."Science 271:1873-1876(1996) [PubMed] [Europe PMC] [Abstract]
  4. "EAF1, a novel ELL-associated factor that is delocalized by expression of the MLL-ELL fusion protein."Blood 98:201-209(2001) [PubMed] [Europe PMC] [Abstract]
  5. "ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties."Blood 101:2355-2362(2003) [PubMed] [Europe PMC] [Abstract]
  6. "ELL and EAF1 are Cajal body components that are disrupted in MLL-ELL leukemia."Mol. Biol. Cell 14:1517-1528(2003) [PubMed] [Europe PMC] [Abstract]
  7. "ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL."Proc. Natl. Acad. Sci. U.S.A. 102:10094-10098(2005) [PubMed] [Europe PMC] [Abstract]
  8. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription."Mol. Cell 38:428-438(2010) [PubMed] [Europe PMC] [Abstract]
  11. "AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia."Mol. Cell 37:429-437(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "The little elongation complex regulates small nuclear RNA transcription."Mol. Cell 44:954-965(2011) [PubMed] [Europe PMC] [Abstract]
  14. "ELL facilitates RNA polymerase II pause site entry and release."Nat. Commun. 3:633-633(2012) [PubMed] [Europe PMC] [Abstract]
  15. "The super elongation complex (SEC) family in transcriptional control."Nat. Rev. Mol. Cell Biol. 13:543-547(2012) [PubMed] [Europe PMC] [Abstract]
  16. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  17. "The little elongation complex functions at initiation and elongation phases of snRNA gene transcription."Mol. Cell 51:493-505(2013) [PubMed] [Europe PMC] [Abstract]
  18. "Solution structure of the helical domain in human eleven-nineteen lysine-rich leukemia protein ELL."Submitted (MAY-2007) to the PDB data bank