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Ectonucleoside Triphosphate Diphosphohydrolase 5 (ENTPD5)

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CD39L4; NTPDase-5; PCPH; CD39 antigen-like 4; Guanosine-diphosphatase ENTPD5; Nucleoside diphosphatase; Uridine-diphosphatase ENTPD5

Ectonucleoside Triphosphate Diphosphohydrolase 5 (ENTPD5)
CCC J155
HGNC 3367
MGI 1321385
PubMed 21074248
RGD 735219
UniProt O75356
Wiki ENTPD5
ENTPD5 is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases.The coding regions of the mouse and human CD39L4 genes share 88% nucleotide sequence identity.
The predicted 428-amino acid CD39L4 protein contains all 4 ACRs, a single N-terminal transmembrane segment, and a large extracellular C-terminal domain. Northern blot analysis revealed that CD39L4 was expressed as a 4.8-kb mRNA in all tissues tested. Several smaller bands were also observed in tissues with the strongest CD39L4 expression.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ectonucleoside Triphosphate Diphosphohydrolase 5 (ENTPD5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ectonucleoside Triphosphate Diphosphohydrolase 5 (ENTPD5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ectonucleoside Triphosphate Diphosphohydrolase 5 (ENTPD5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ectonucleoside Triphosphate Diphosphohydrolase 5 (ENTPD5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ectonucleoside Triphosphate Diphosphohydrolase 5 (ENTPD5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ectonucleoside Triphosphate Diphosphohydrolase 5 (ENTPD5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ectonucleoside Triphosphate Diphosphohydrolase 5 (ENTPD5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ectonucleoside Triphosphate Diphosphohydrolase 5 (ENTPD5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ectonucleoside Triphosphate Diphosphohydrolase 5 (ENTPD5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ectonucleoside Triphosphate Diphosphohydrolase 5 (ENTPD5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ectonucleoside Triphosphate Diphosphohydrolase 5 (ENTPD5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ectonucleoside Triphosphate Diphosphohydrolase 5 (ENTPD5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ectonucleoside Triphosphate Diphosphohydrolase 5 (ENTPD5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ectonucleoside Triphosphate Diphosphohydrolase 5 (ENTPD5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ectonucleoside Triphosphate Diphosphohydrolase 5 (ENTPD5) ELISA Kit Customized Service Offer
  1. "The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster."Genomics 50:357-367(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The human PCPH proto-oncogene: cDNA identification, primary structure, chromosomal mapping, and expression in normal and tumor cells."Mol. Carcinog. 27:229-236(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Bacterial expression, folding, purification and characterization of soluble NTPDase5 (CD39L4) ecto-nucleotidase."Biochim. Biophys. Acta 1747:251-259(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "CD39-L4 is a secreted human apyrase, specific for the hydrolysis of nucleoside diphosphates."J. Biol. Chem. 274:20064-20067(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Biochemical characterization of CD39L4."Biochemistry 39:12924-12928(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  10. "The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway."Cell 143:711-724(2010) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]