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Epoxide Hydrolase 2, Cytoplasmic (EPHX2)

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CEH; SEH; Bifunctional epoxide hydrolase 2; Cytosolic epoxide hydrolase 2; Epoxide hydratase; Soluble epoxide hydrolase; Lipid-phosphate phosphatase

Epoxide Hydrolase 2, Cytoplasmic (EPHX2)
CCC J145
HGNC 3402
MGI 99500
PubMed 23999524
RGD 620732
UniProt P34913
Wiki EPHX2
EPHX2 encodes a member of the epoxide hydrolase family. The protein, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding dihydrodiols. Mutations in this gene have been associated with familial hypercholesterolemia. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
The coding sequence corresponded to 555 amino acids, which the authors noted included 1 additional residue compared to the reported cDNA sequence. Putative sites for phosphorylation, myristoylation, amidation, and peroxisomal targeting, as well as a leucine zipper, were detected.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Epoxide Hydrolase 2, Cytoplasmic (EPHX2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Epoxide Hydrolase 2, Cytoplasmic (EPHX2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Epoxide Hydrolase 2, Cytoplasmic (EPHX2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Epoxide Hydrolase 2, Cytoplasmic (EPHX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Epoxide Hydrolase 2, Cytoplasmic (EPHX2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Epoxide Hydrolase 2, Cytoplasmic (EPHX2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Epoxide Hydrolase 2, Cytoplasmic (EPHX2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Epoxide Hydrolase 2, Cytoplasmic (EPHX2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Epoxide Hydrolase 2, Cytoplasmic (EPHX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Epoxide Hydrolase 2, Cytoplasmic (EPHX2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Epoxide Hydrolase 2, Cytoplasmic (EPHX2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Epoxide Hydrolase 2, Cytoplasmic (EPHX2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Epoxide Hydrolase 2, Cytoplasmic (EPHX2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Epoxide Hydrolase 2, Cytoplasmic (EPHX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Epoxide Hydrolase 2, Cytoplasmic (EPHX2) ELISA Kit Customized Service Offer
  1. "cDNA cloning and expression of a soluble epoxide hydrolase from human liver."Arch. Biochem. Biophys. 305:197-201(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Structural characterization of the human soluble epoxide hydrolase gene (EPHX2)."Biochem. Biophys. Res. Commun. 221:333-339(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Identification and functional characterization of human soluble epoxide hydrolase genetic polymorphisms."J. Biol. Chem. 275:28873-28881(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Polymorphisms in human soluble epoxide hydrolase."Mol. Pharmacol. 64:482-490(2003) [PubMed] [Europe PMC] [Abstract]
  8. "The N-terminal domain of mammalian soluble epoxide hydrolase is a phosphatase."Proc. Natl. Acad. Sci. U.S.A. 100:1552-1557(2003) [PubMed] [Europe PMC] [Abstract]
  9. "The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity."Proc. Natl. Acad. Sci. U.S.A. 100:1558-1563(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Polymorphisms in human soluble epoxide hydrolase: effects on enzyme activity, enzyme stability, and quaternary structure."Arch. Biochem. Biophys. 427:164-169(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Redox regulation of soluble epoxide hydrolase by 15-deoxy-delta-prostaglandin J2 controls coronary hypoxic vasodilation."Circ. Res. 108:324-334(2011) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis."Biochemistry 43:4716-4723(2004) [PubMed] [Europe PMC] [Abstract]
  16. "Human soluble epoxide hydrolase: structural basis of inhibition by 4-(3-cyclohexylureido)-carboxylic acids."Protein Sci. 15:58-64(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase."J. Med. Chem. 52:5880-5895(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Optimization of piperidyl-ureas as inhibitors of soluble epoxide hydrolase."Bioorg. Med. Chem. Lett. 20:571-575(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Substituted pyrazoles as novel sEH antagonist: investigation of key binding interactions within the catalytic domain."Bioorg. Med. Chem. Lett. 20:6379-6383(2010) [PubMed] [Europe PMC] [Abstract]