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Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8)

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Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8)
CCC J140
HGNC 3420
MGI 104684
PubMed 17496330
RGD 1310590
UniProt Q12929
Wiki EPS8
EPS8 encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
EPS8 was expressed in all epithelial and fibroblast cell lines examined and in some, but not all, hematopoietic cells. An essential function of EPS8 in cell growth regulation was underscored by its conservation during evolution, as EPS8-related sequences were detected as early as in S. cerevisiae.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) ELISA Kit Customized Service Offer
  1. "Evolutionary conservation of the EPS8 gene and its mapping to human chromosome 12q23-q24."Oncogene 9:3057-3061(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins."Oncogene 10:1475-1483(1995) [PubMed] [Europe PMC] [Abstract]
  6. "Overexpression of p97Eps8 leads to cellular transformation: implication of pleckstrin homology domain in p97Eps8-mediated ERK activation."Oncogene 20:106-112(2001) [PubMed] [Europe PMC] [Abstract]
  7. "IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasiveness."Cancer Res. 64:5237-5244(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Eps8 controls actin-based motility by capping the barbed ends of actin filaments."Nat. Cell Biol. 6:1180-1188(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex."Nat. Cell Biol. 8:1337-1347(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Eps8 is increased in pancreatic cancer and required for dynamic actin-based cell protrusions and intercellular cytoskeletal organization."Cancer Lett. 255:205-218(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Eps8 decreases chemosensitivity and affects survival of cervical cancer patients."Mol. Cancer Ther. 7:1376-1385(2008) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Role for EPS8 in squamous carcinogenesis."Carcinogenesis 30:165-174(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Epidermal growth factor receptor pathway substrate 8 is overexpressed in human pituitary tumors: role in proliferation and survival."Endocrinology 150:2064-2071(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Upregulation of Eps8 in oral squamous cell carcinoma promotes cell migration and invasion through integrin-dependent Rac1 activation."Oncogene 28:2524-2534(2009) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "EPS8, encoding an actin-binding protein of cochlear hair cell stereocilia, is a new causal gene for autosomal recessive profound deafness."Orphanet J. Rare Dis. 9:55-55(2014) [PubMed] [Europe PMC] [Abstract]
  19. "Solution structure of the C-terminal SAM-domain of epidermal growth receptor pathway substrate 8."Submitted (JUL-2007) to the PDB data bank