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Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15)

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AF-1P; AF1P; MLLT5

Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15)
CCC J139
HGNC 3419
MGI 104583
PubMed 9490719
RGD 1305550
UniProt P42566
Wiki EPS15
EPS15 encodes a protein that is part of the EGFR pathway. The protein is present at clathrin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Binding of the parkin ubiquitin-like domain to the Eps15 ubiquitin-interacting motifs was required for parkin-mediated Eps15 ubiquitination. Egfr endocytosis and degradation were accelerated in parkin-deficient cells, and Egfr signaling via the PI3K-Akt pathway was reduced in parkin-knockout mouse brain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) CLIA Kit Customized Service Offer
n/a ELISA Kit for Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) CLIA Kit Customized Service Offer
n/a ELISA Kit for Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) CLIA Kit Customized Service Offer
n/a ELISA Kit for Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) ELISA Kit Customized Service Offer
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