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Establishment Of Cohesion 1 Homolog 2 (ESCO2)

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RBS; EFO2; Roberts Syndrome; N-acetyltransferase ESCO2

Establishment Of Cohesion 1 Homolog 2 (ESCO2)
CCC J134
HGNC 27230
MGI 1919238
PubMed 22101327
RGD 1593313
UniProt Q56NI9
Wiki ESCO2
The C-terminal half of EFO2 possessed autoacetylation activity. RNA interference in HeLa cells showed that EFO2 was required for sister chromatid cohesion. There was a significant increase in mitotic cells with unpaired chromatids (65%) when EFO2 was depleted and a further increase in unpaired chromatids (93%) when both EFO1 and EFO2 were reduced simultaneously.The cDNA open reading frame of 1,806 nucleotides predicted a protein of 601 amino acids.
Similarity to orthologs in several vertebrates indicated evolutionary conservation. The ESCO2 protein product is a member of a conserved protein family that is required for the establishment of sister chromatid cohesion during S phase and has putative acetyltransferase activity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Establishment Of Cohesion 1 Homolog 2 (ESCO2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Establishment Of Cohesion 1 Homolog 2 (ESCO2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Establishment Of Cohesion 1 Homolog 2 (ESCO2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Establishment Of Cohesion 1 Homolog 2 (ESCO2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Establishment Of Cohesion 1 Homolog 2 (ESCO2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Establishment Of Cohesion 1 Homolog 2 (ESCO2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Establishment Of Cohesion 1 Homolog 2 (ESCO2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Establishment Of Cohesion 1 Homolog 2 (ESCO2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Establishment Of Cohesion 1 Homolog 2 (ESCO2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Establishment Of Cohesion 1 Homolog 2 (ESCO2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Establishment Of Cohesion 1 Homolog 2 (ESCO2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Establishment Of Cohesion 1 Homolog 2 (ESCO2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Establishment Of Cohesion 1 Homolog 2 (ESCO2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Establishment Of Cohesion 1 Homolog 2 (ESCO2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Establishment Of Cohesion 1 Homolog 2 (ESCO2) ELISA Kit Customized Service Offer
  1. "Roberts syndrome is caused by mutations in ESCO2, a human homolog of yeast ECO1 that is essential for the establishment of sister chromatid cohesion."Nat. Genet. 37:468-470(2005) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Inactivating mutations in ESCO2 cause SC phocomelia and Roberts syndrome: no phenotype-genotype correlation."Am. J. Hum. Genet. 77:1117-1128(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Cohesin acetylation speeds the replication fork."Nature 462:231-234(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Sororin mediates sister chromatid cohesion by antagonizing wapl."Cell 143:737-749(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]