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F-Box And Leucine Rich Repeat Protein 2 (FBXL2)

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FBL2; F-box protein FBL2/FBL3; F-box/LRR-repeat protein 2

F-Box And Leucine Rich Repeat Protein 2 (FBXL2)
CCC J120
HGNC 13598
MGI 1919429
PubMed 23604317
UniProt Q9UKC9
Wiki FBXL2
FBXL2 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs.
The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats.Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant F-Box And Leucine Rich Repeat Protein 2 (FBXL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to F-Box And Leucine Rich Repeat Protein 2 (FBXL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to F-Box And Leucine Rich Repeat Protein 2 (FBXL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for F-Box And Leucine Rich Repeat Protein 2 (FBXL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for F-Box And Leucine Rich Repeat Protein 2 (FBXL2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant F-Box And Leucine Rich Repeat Protein 2 (FBXL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to F-Box And Leucine Rich Repeat Protein 2 (FBXL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to F-Box And Leucine Rich Repeat Protein 2 (FBXL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for F-Box And Leucine Rich Repeat Protein 2 (FBXL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for F-Box And Leucine Rich Repeat Protein 2 (FBXL2) ELISA Kit Customized Service Offer
  1. "Identification of a family of human F-box proteins."Curr. Biol. 9:1177-1179(1999) [PubMed] [Europe PMC] [Abstract]
  2. "A family of mammalian F-box proteins."Curr. Biol. 9:1180-1182(1999) [PubMed] [Europe PMC] [Abstract]
  3. "cDNA cloning and expression analysis of new members of the mammalian F-box protein family."Genomics 67:40-47(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication."Mol. Cell 18:425-434(2005) [PubMed] [Europe PMC] [Abstract]
  9. "F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation."Blood 119:3132-3141(2012) [PubMed] [Europe PMC] [Abstract]
  10. "F-box protein FBXL2 exerts human lung tumor suppressor-like activity by ubiquitin-mediated degradation of cyclin D3 resulting in cell cycle arrest."Oncogene 31:2566-2579(2012) [PubMed] [Europe PMC] [Abstract]
  11. "FBXL2- and PTPL1-mediated degradation of p110-free p85beta regulatory subunit controls the PI(3)K signalling cascade."Nat. Cell Biol. 15:472-480(2013) [PubMed] [Europe PMC] [Abstract]
  12. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]