≡

F-Box And Leucine Rich Repeat Protein 4 (FBXL4)

[Edit]

FBL4; F-box protein FBL4/FBL5; F-box/LRR-repeat protein 4

F-Box And Leucine Rich Repeat Protein 4 (FBXL4)
CCC J119
HGNC 13601
MGI 2140367
PubMed 23993194
RGD 1305724
UniProt Q9UKA2
Wiki FBXL4
FBXL4 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs.
The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least 9 tandem leucine-rich repeats.Expressed in heart, kidney, liver, lung, pancreas, and placenta, but not in skeletal muscle.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant F-Box And Leucine Rich Repeat Protein 4 (FBXL4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to F-Box And Leucine Rich Repeat Protein 4 (FBXL4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to F-Box And Leucine Rich Repeat Protein 4 (FBXL4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for F-Box And Leucine Rich Repeat Protein 4 (FBXL4) CLIA Kit Customized Service Offer
n/a ELISA Kit for F-Box And Leucine Rich Repeat Protein 4 (FBXL4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant F-Box And Leucine Rich Repeat Protein 4 (FBXL4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to F-Box And Leucine Rich Repeat Protein 4 (FBXL4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to F-Box And Leucine Rich Repeat Protein 4 (FBXL4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for F-Box And Leucine Rich Repeat Protein 4 (FBXL4) CLIA Kit Customized Service Offer
n/a ELISA Kit for F-Box And Leucine Rich Repeat Protein 4 (FBXL4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant F-Box And Leucine Rich Repeat Protein 4 (FBXL4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to F-Box And Leucine Rich Repeat Protein 4 (FBXL4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to F-Box And Leucine Rich Repeat Protein 4 (FBXL4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for F-Box And Leucine Rich Repeat Protein 4 (FBXL4) CLIA Kit Customized Service Offer
n/a ELISA Kit for F-Box And Leucine Rich Repeat Protein 4 (FBXL4) ELISA Kit Customized Service Offer
  1. "A family of mammalian F-box proteins."Curr. Biol. 9:1180-1182(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of a family of human F-box proteins."Curr. Biol. 9:1177-1179(1999) [PubMed] [Europe PMC] [Abstract]
  3. "cDNA cloning and expression analysis of new members of the mammalian F-box protein family."Genomics 67:40-47(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Mutations in FBXL4 cause mitochondrial encephalopathy and a disorder of mitochondrial DNA maintenance." Am. J. Hum. Genet. 93:471-481(2013) [PubMed] [Europe PMC] [Abstract]
  8. "Mutations in FBXL4, encoding a mitochondrial protein, cause early-onset mitochondrial encephalomyopathy." Am. J. Hum. Genet. 93:482-495(2013) [PubMed] [Europe PMC] [Abstract]