≡

F-Box And Leucine Rich Repeat Protein 5 (FBXL5)

[Edit]

FBL4; FBL5; FLR1; F-box/LRR-repeat protein 5; F-box protein FBL4/FBL5; p45SKP2-like protein

F-Box And Leucine Rich Repeat Protein 5 (FBXL5)
CCC J115
HGNC 13602
MGI 2152883
PubMed 24157836
RGD 1306887
UniProt Q9UKA1
Wiki FBXL5
FBXL5 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs.
The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternative splicing of this gene generates 2 transcript variants.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant F-Box And Leucine Rich Repeat Protein 5 (FBXL5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to F-Box And Leucine Rich Repeat Protein 5 (FBXL5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to F-Box And Leucine Rich Repeat Protein 5 (FBXL5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for F-Box And Leucine Rich Repeat Protein 5 (FBXL5) CLIA Kit Customized Service Offer
n/a ELISA Kit for F-Box And Leucine Rich Repeat Protein 5 (FBXL5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant F-Box And Leucine Rich Repeat Protein 5 (FBXL5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to F-Box And Leucine Rich Repeat Protein 5 (FBXL5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to F-Box And Leucine Rich Repeat Protein 5 (FBXL5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for F-Box And Leucine Rich Repeat Protein 5 (FBXL5) CLIA Kit Customized Service Offer
n/a ELISA Kit for F-Box And Leucine Rich Repeat Protein 5 (FBXL5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant F-Box And Leucine Rich Repeat Protein 5 (FBXL5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to F-Box And Leucine Rich Repeat Protein 5 (FBXL5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to F-Box And Leucine Rich Repeat Protein 5 (FBXL5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for F-Box And Leucine Rich Repeat Protein 5 (FBXL5) CLIA Kit Customized Service Offer
n/a ELISA Kit for F-Box And Leucine Rich Repeat Protein 5 (FBXL5) ELISA Kit Customized Service Offer
  1. "A family of mammalian F-box proteins."Curr. Biol. 9:1180-1182(1999) [PubMed] [Europe PMC] [Abstract]
  2. "cDNA cloning and expression analysis of new members of the mammalian F-box protein family."Genomics 67:40-47(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of a family of human F-box proteins."Curr. Biol. 9:1177-1179(1999) [PubMed] [Europe PMC] [Abstract]
  8. "FBXL5 interacts with p150Glued and regulates its ubiquitination."Biochem. Biophys. Res. Commun. 359:34-39(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Control of iron homeostasis by an iron-regulated ubiquitin ligase."Science 326:718-721(2009) [PubMed] [Europe PMC] [Abstract]
  10. "An E3 ligase possessing an iron responsive hemerythrin domain is a regulator of iron homeostasis."Science 326:722-726(2009) [PubMed] [Europe PMC] [Abstract]
  11. "The structural basis of iron sensing by the human F-box protein FBXL5."ChemBioChem 13:788-791(2012) [PubMed] [Europe PMC] [Abstract]
  12. "Structural and molecular characterization of iron-sensing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5)."J. Biol. Chem. 287:7357-7365(2012) [PubMed] [Europe PMC] [Abstract]