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Follistatin Like Protein 3 (FSTL3)

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FLRG; FSRP; Follistatin-Related Protein,Secreted Glycoprotein; Follistatin-related gene protein

Follistatin Like Protein 3 (FSTL3)
CCC J084
HGNC 3973
MGI 1890391
PubMed 23407452
RGD 621811
UniProt O95633
Wiki FSTL3
Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis.The FSTL3 cDNA, which they called FLRG (follistatin-related gene), encodes a deduced 263-amino acid protein that shares 85% amino acid identity with mouse Fstl3. It contains 2 cysteine-rich repeats that are closely related to the class 1-1 follistatin modules present in other follistatin family members. Northern blot analysis demonstrated expression of a 2.5-kb transcript in placenta, amniocytes, chorionic villosities, and bone marrow stromal cells, with weaker expression in fibroblasts, keratinocytes, and endothelial cells. A 1.3-kb transcript was also detected in some human tissues and was thought to result from use of an alternate polyadenylation site.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Follistatin Like Protein 3 (FSTL3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Follistatin Like Protein 3 (FSTL3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Follistatin Like Protein 3 (FSTL3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Follistatin Like Protein 3 (FSTL3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Follistatin Like Protein 3 (FSTL3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ084Mu01 Recombinant Follistatin Like Protein 3 (FSTL3) Positive Control; Immunogen; SDS-PAGE; WB.
RPJ084Mu02 Recombinant Follistatin Like Protein 3 (FSTL3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ084Mu01 Polyclonal Antibody to Follistatin Like Protein 3 (FSTL3) WB; IHC
PAJ084Mu02 Polyclonal Antibody to Follistatin Like Protein 3 (FSTL3) WB; IHC; ICC; IP.
Assay Kits SEJ084Mu ELISA Kit for Follistatin Like Protein 3 (FSTL3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Follistatin Like Protein 3 (FSTL3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Follistatin Like Protein 3 (FSTL3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Follistatin Like Protein 3 (FSTL3) Polyclonal Antibody Customized Service Offer
Assay Kits SEJ084Ra ELISA Kit for Follistatin Like Protein 3 (FSTL3) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "FLRG (follistatin-related gene), a new target of chromosomal rearrangement in malignant blood disorders."Oncogene 16:2949-2954(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Human follistatin-related protein: a structural homologue of follistatin with nuclear localization."Endocrinology 142:3426-3434(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Transcription activation of FLRG and follistatin by activin A, through Smad proteins, participates in a negative feedback loop to modulate activin A function."Oncogene 21:2227-2235(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Differential binding and neutralization of activins A and B by follistatin and follistatin like-3 (FSTL-3/FSRP/FLRG)."Endocrinology 144:1671-1674(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Follistatin-related gene (FLRG) expression in human endometrium: sex steroid hormones regulate the expression of FLRG in cultured human endometrial stromal cells."J. Clin. Endocrinol. Metab. 88:4432-4439(2003) [PubMed] [Europe PMC] [Abstract]
  10. "FLRG, member of the follistatin family, a new player in hematopoiesis."Mol. Cell. Endocrinol. 225:109-118(2004) [PubMed] [Europe PMC] [Abstract]
  11. "FLRG, a new ADAM12-associated protein, modulates osteoclast differentiation."Biol. Cell 97:577-588(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Differential biosynthesis and intracellular transport of follistatin isoforms and follistatin-like-3."Endocrinology 146:5052-5062(2005) [PubMed] [Europe PMC] [Abstract]
  13. "A novel role for fibronectin type I domain in the regulation of human hematopoietic cell adhesiveness through binding to follistatin domains of FLRG and follistatin."Exp. Cell Res. 312:434-442(2006) [PubMed] [Europe PMC] [Abstract]
  14. "AF10-dependent transcription is enhanced by its interaction with FLRG."Biol. Cell 99:563-571(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Characterization of follistatin-related gene as a negative regulatory factor for activin family members during mouse heart development."J. Med. Invest. 54:276-288(2007) [PubMed] [Europe PMC] [Abstract]
  16. "The structure of FSTL3.activin A complex. Differential binding of N-terminal domains influences follistatin-type antagonist specificity."J. Biol. Chem. 283:32831-32838(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Structure of myostatin.follistatin-like 3: N-terminal domains of follistatin-type molecules exhibit alternate modes of binding."J. Biol. Chem. 287:1043-1053(2012) [PubMed] [Europe PMC] [Abstract]