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GABA-A Receptor Associated Protein (GABARAP)

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MM46; Gamma-aminobutyric acid receptor-associated protein

GABA-A Receptor Associated Protein (GABARAP)
CCC J078
HGNC 4067
MGI 1861742
PubMed 23427251
RGD 61911
UniProt O95166
Wiki GABARAP
Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton.
A study has screened 2000 participants representing more than 600 families of smokers and examined different genes showing linkage to nicotine addiction. Some of these showing linkage are the GABA-B receptor subunit 2 (GABAB2) gene on chromosome 9, and the GABARAP) gene on chromosome 17.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GABA-A Receptor Associated Protein (GABARAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GABA-A Receptor Associated Protein (GABARAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GABA-A Receptor Associated Protein (GABARAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GABA-A Receptor Associated Protein (GABARAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for GABA-A Receptor Associated Protein (GABARAP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GABA-A Receptor Associated Protein (GABARAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GABA-A Receptor Associated Protein (GABARAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GABA-A Receptor Associated Protein (GABARAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GABA-A Receptor Associated Protein (GABARAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for GABA-A Receptor Associated Protein (GABARAP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GABA-A Receptor Associated Protein (GABARAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GABA-A Receptor Associated Protein (GABARAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GABA-A Receptor Associated Protein (GABARAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GABA-A Receptor Associated Protein (GABARAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for GABA-A Receptor Associated Protein (GABARAP) ELISA Kit Customized Service Offer
  1. "GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton."Nature 397:69-72(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation."Brain Res. Mol. Brain Res. 85:1-12(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3."J. Biol. Chem. 276:1701-1706(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p."J. Biol. Chem. 277:13739-13744(2002) [PubMed] [Europe PMC] [Abstract]
  6. "GATE-16 and GABARAP are authentic modifiers mediated by Apg7 and Apg3."Biochem. Biophys. Res. Commun. 300:637-644(2003) [PubMed] [Europe PMC] [Abstract]
  7. "LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation."J. Cell Sci. 117:2805-2812(2004) [PubMed] [Europe PMC] [Abstract]
  8. "GABAA receptor-associated protein (GABARAP) induces apoptosis by interacting with DEAD (Asp-Glu-Ala-Asp/His) box polypeptide 47 (DDX 47)."Biotechnol. Lett. 27:623-628(2005) [PubMed] [Europe PMC] [Abstract]
  9. "p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy."J. Biol. Chem. 282:24131-24145(2007) [PubMed] [Europe PMC] [Abstract]
  10. "The TP53INP2 protein is required for autophagy in mammalian cells."Mol. Biol. Cell 20:870-881(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Network organization of the human autophagy system."Nature 466:68-76(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation."J. Cell Biol. 192:839-853(2011) [PubMed] [Europe PMC] [Abstract]
  14. "MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins."Autophagy 8:1724-1740(2012) [PubMed] [Europe PMC] [Abstract]
  15. "TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death."Cell Death Differ. 19:1525-1535(2012) [PubMed] [Europe PMC] [Abstract]
  16. "ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs."J. Biol. Chem. 287:39275-39290(2012) [PubMed] [Europe PMC] [Abstract]
  17. "Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers."Mol. Cell. Biol. 32:1733-1744(2012) [PubMed] [Europe PMC] [Abstract]
  18. "DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription."PLoS ONE 7:E34034-E34034(2012) [PubMed] [Europe PMC] [Abstract]
  19. "Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites."Nature 502:254-257(2013) [PubMed] [Europe PMC] [Abstract]
  20. "The X-ray crystal structure and putative ligand-derived peptide binding properties of gamma-aminobutyric acid receptor type A receptor-associated protein."J. Biol. Chem. 277:5556-5561(2002) [PubMed] [Europe PMC] [Abstract]
  21. "Solution structure of human GABA(A) receptor-associated protein GABARAP: implications for biological function and its regulation."J. Biol. Chem. 277:13363-13366(2002) [PubMed] [Europe PMC] [Abstract]
  22. "1H, 13C and '5N resonance assignments of GABARAP, GABAA receptor associated protein."J. Biomol. NMR 22:97-98(2002) [PubMed] [Europe PMC] [Abstract]
  23. "Ligand binding mode of GABAA receptor-associated protein."J. Mol. Biol. 381:1320-1331(2008) [PubMed] [Europe PMC] [Abstract]
  24. "Structural framework of the GABARAP-calreticulin interface --implications for substrate binding to endoplasmic reticulum chaperones."FEBS J. 276:1140-1152(2009) [PubMed] [Europe PMC] [Abstract]