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Golgi Brefeldin A Resistant Guanine Nucleotide Exchange Factor 1 (GBF1)

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ARF1GEF; Golgi-Specific Brefeldin A Resistance Factor 1

Golgi Brefeldin A Resistant Guanine Nucleotide Exchange Factor 1 (GBF1)
CCC J064
HGNC 4181
MGI 1861607
PubMed 22359663
RGD 1307160
UniProt Q92538
Wiki GBF1
Members of the Sec7 domain family share a conserved region that forms a catalytic fold with guanine nucleotide exchange activity. In vitro, the Sec7 domain of several proteins catalyzes the activation of ADP-ribosylation factors (ARFs), suggesting that members of the Sec7 domain family represent specific guanine nucleotide exchange factors for the ARF GTPase family. Using 5-prime RACE, Mansour et al. (1998) isolated a cDNA corresponding to the remainder of the coding sequence. They designated the gene GBF1 (Golgi-specific brefeldin A resistance factor-1). The predicted 1,859-amino acid protein has a pI of 5.55 and contains a Sec7 domain and a proline-rich C terminus. A 7-kb GBF1 mRNA was expressed in all tissues tested by Northern blot analysis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Golgi Brefeldin A Resistant Guanine Nucleotide Exchange Factor 1 (GBF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Golgi Brefeldin A Resistant Guanine Nucleotide Exchange Factor 1 (GBF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Golgi Brefeldin A Resistant Guanine Nucleotide Exchange Factor 1 (GBF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Golgi Brefeldin A Resistant Guanine Nucleotide Exchange Factor 1 (GBF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Golgi Brefeldin A Resistant Guanine Nucleotide Exchange Factor 1 (GBF1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Golgi Brefeldin A Resistant Guanine Nucleotide Exchange Factor 1 (GBF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Golgi Brefeldin A Resistant Guanine Nucleotide Exchange Factor 1 (GBF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Golgi Brefeldin A Resistant Guanine Nucleotide Exchange Factor 1 (GBF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Golgi Brefeldin A Resistant Guanine Nucleotide Exchange Factor 1 (GBF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Golgi Brefeldin A Resistant Guanine Nucleotide Exchange Factor 1 (GBF1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Golgi Brefeldin A Resistant Guanine Nucleotide Exchange Factor 1 (GBF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Golgi Brefeldin A Resistant Guanine Nucleotide Exchange Factor 1 (GBF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Golgi Brefeldin A Resistant Guanine Nucleotide Exchange Factor 1 (GBF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Golgi Brefeldin A Resistant Guanine Nucleotide Exchange Factor 1 (GBF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Golgi Brefeldin A Resistant Guanine Nucleotide Exchange Factor 1 (GBF1) ELISA Kit Customized Service Offer
  1. "Human GBF1 is a ubiquitously expressed gene of the sec7 domain family mapping to 10q24."Genomics 54:323-327(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "GBF1, a guanine nucleotide exchange factor for ADP-ribosylation factors, is localized to the cis-Golgi and involved in membrane association of the COPI coat."Traffic 3:483-495(2002) [PubMed] [Europe PMC] [Abstract]
  8. "The membrane-tethering protein p115 interacts with GBF1, an ARF guanine-nucleotide-exchange factor."EMBO Rep. 4:320-325(2003) [PubMed] [Europe PMC] [Abstract]
  9. "ADP-ribosylation factor/COPI-dependent events at the endoplasmic reticulum-Golgi interface are regulated by the guanine nucleotide exchange factor GBF1."Mol. Biol. Cell 14:2250-2261(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Dynamics of GBF1, a Brefeldin A-sensitive Arf1 exchange factor at the Golgi."Mol. Biol. Cell 16:1213-1222(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Dissection of membrane dynamics of the ARF-guanine nucleotide exchange factor GBF1."Traffic 6:374-385(2005) [PubMed] [Europe PMC] [Abstract]
  12. "GBF1, a cis-Golgi and VTCs-localized ARF-GEF, is implicated in ER-to-Golgi protein traffic."J. Cell Sci. 119:3743-3753(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Effects of picornavirus 3A Proteins on Protein Transport and GBF1-dependent COP-I recruitment."J. Virol. 80:11852-11860(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Interactions between conserved domains within homodimers in the BIG1, BIG2, and GBF1 Arf guanine nucleotide exchange factors."J. Biol. Chem. 282:28834-28842(2007) [PubMed] [Europe PMC] [Abstract]
  16. "Dissecting the role of the ARF guanine nucleotide exchange factor GBF1 in Golgi biogenesis and protein trafficking."J. Cell Sci. 120:3929-3940(2007) [PubMed] [Europe PMC] [Abstract]
  17. "Rab1b interacts with GBF1 and modulates both ARF1 dynamics and COPI association."Mol. Biol. Cell 18:2400-2410(2007) [PubMed] [Europe PMC] [Abstract]
  18. "The Arf GEF GBF1 is required for GGA recruitment to Golgi membranes."Traffic 8:1440-1451(2007) [PubMed] [Europe PMC] [Abstract]
  19. "AMP-activated protein kinase phosphorylates Golgi-specific brefeldin A resistance factor 1 at Thr1337 to induce disassembly of Golgi apparatus."J. Biol. Chem. 283:4430-4438(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  21. "Distinct functions for Arf guanine nucleotide exchange factors at the Golgi complex: GBF1 and BIGs are required for assembly and maintenance of the Golgi stack and trans-Golgi network, respectively."Mol. Biol. Cell 19:523-535(2008) [PubMed] [Europe PMC] [Abstract]
  22. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  23. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  24. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  25. "A COPI coat subunit interacts directly with an early-Golgi localized Arf exchange factor."EMBO Rep. 10:58-64(2009) [PubMed] [Europe PMC] [Abstract]
  26. "Coatomer-dependent protein delivery to lipid droplets."J. Cell Sci. 122:1834-1841(2009) [PubMed] [Europe PMC] [Abstract]
  27. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  28. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  29. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  30. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  31. "GBF1-Arf-COPI-ArfGAP-mediated Golgi-to-ER transport involved in regulation of lipid homeostasis."Cell Struct. Funct. 36:223-235(2011) [PubMed] [Europe PMC] [Abstract]
  32. "Interaction between the triglyceride lipase ATGL and the Arf1 activator GBF1."PLoS ONE 6:E21889-E21889(2011) [PubMed] [Europe PMC] [Abstract]
  33. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  34. "GBF1 bears a novel phosphatidylinositol-phosphate binding module, BP3K, to link PI3Kgamma activity with Arf1 activation involved in GPCR-mediated neutrophil chemotaxis and superoxide production."Mol. Biol. Cell 23:2457-2467(2012) [PubMed] [Europe PMC] [Abstract]
  35. "The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN)."J. Biol. Chem. 288:11532-11545(2013) [PubMed] [Europe PMC] [Abstract]
  36. "AMPK phosphorylates GBF1 for mitotic Golgi disassembly."J. Cell Sci. 126:1498-1505(2013) [PubMed] [Europe PMC] [Abstract]
  37. "Arf activation at the Golgi is modulated by feed-forward stimulation of the exchange factor GBF1."J. Cell Sci. 127:354-364(2014) [PubMed] [Europe PMC] [Abstract]
  38. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]