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Glial Cells Missing Homolog 2 (GCM2)

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GCMB; hGCMb; GCM motif protein 2; Chorion-specific transcription factor GCMb

Glial Cells Missing Homolog 2 (GCM2)
CCC J055
HGNC 4198
MGI 1861438
PubMed 17382312
RGD 1311127
UniProt O75603
Wiki GCM2
GCM2 is a homolog of the Drosophila glial cells missing gene, which is thought to act as a binary switch between neuronal and glial cell determination. The protein encoded by this gene contains a conserved N-terminal GCM motif that has DNA-binding activity. The protein is a transcription factor that acts as a master regulator of parathyroid development. It has been suggested that this transcription factor might mediate the effect of calcium on parathyroid hormone expression and secretion in parathyroid cells.The predicted 506-amino acid GCMB protein contains the structures common to all gcm family members, including a gcm motif and PEST-like sequence. In addition, both human and mouse GCMB have a nuclear targeting sequence. Overall, the GCMB protein shares 68% and 47% similarity with Gcmb and GCMA, respectively.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glial Cells Missing Homolog 2 (GCM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glial Cells Missing Homolog 2 (GCM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glial Cells Missing Homolog 2 (GCM2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glial Cells Missing Homolog 2 (GCM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glial Cells Missing Homolog 2 (GCM2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glial Cells Missing Homolog 2 (GCM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glial Cells Missing Homolog 2 (GCM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glial Cells Missing Homolog 2 (GCM2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glial Cells Missing Homolog 2 (GCM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glial Cells Missing Homolog 2 (GCM2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glial Cells Missing Homolog 2 (GCM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glial Cells Missing Homolog 2 (GCM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glial Cells Missing Homolog 2 (GCM2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glial Cells Missing Homolog 2 (GCM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glial Cells Missing Homolog 2 (GCM2) ELISA Kit Customized Service Offer
  1. "Isolation and expression analysis of a novel human homologue of the Drosophila glial cells missing (gcm) gene."FEBS Lett. 442:151-156(1999) [PubMed] [Europe PMC] [Abstract]
  2. "GCMB, a second human homolog of the fly glide/gcm gene."Cytogenet. Cell Genet. 84:43-47(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "GCMB mutation in familial isolated hypoparathyroidism with residual secretion of parathyroid hormone."J. Clin. Endocrinol. Metab. 90:2487-2492(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of a novel mutation disrupting the DNA binding activity of GCM2 in autosomal recessive familial isolated hypoparathyroidism."J. Med. Genet. 42:443-448(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Identification and characterization of novel parathyroid-specific transcription factor Glial Cells Missing Homolog B (GCMB) mutations in eight families with autosomal recessive hypoparathyroidism."Hum. Mol. Genet. 19:2028-2038(2010) [PubMed] [Europe PMC] [Abstract]
  8. "A missense glial cells missing homolog B (GCMB) mutation, Asn502His, causes autosomal dominant hypoparathyroidism."J. Clin. Endocrinol. Metab. 95:3512-3516(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Mutational analysis of GCMB, a parathyroid-specific transcription factor, in parathyroid adenoma of primary hyperparathyroidism."J. Endocrinol. 210:165-171(2011) [PubMed] [Europe PMC] [Abstract]