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Gamma-Glutamylcyclotransferase (gGCT)

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GCTG; CRF21; Ggc; C7orf24; Cytochrome c-releasing factor 21

Gamma-Glutamylcyclotransferase (gGCT)
CCC J050
HGNC 21705
MGI 1915502
PubMed 18515354
UniProt O75223
Wiki GGCT
GGCT (EC 2.3.2.4) catalyzes the formation of 5-oxoproline (pyroglutamic acid) from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis.
The deduced 188-amino acid protein has a calculated molecular mass of 21 kD. EST database analysis revealed moderate GGCT expression in a wide range of human tissues, with highest levels in bladder and salivary gland. Database analysis identified GGCT orthologs in a range of species from C. elegans to mammals, but not in plants.GGO-induced apoptosis was inhibited by a dominant-negative mutation of JNK (MAPK8) that impeded JNK signaling, suggesting involvement of JNK and CRF21 in GGO-induced apoptosis.The enzymatic kinetics were similar to those of GGCT purified from human erythrocytes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Gamma-Glutamylcyclotransferase (gGCT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Gamma-Glutamylcyclotransferase (gGCT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Gamma-Glutamylcyclotransferase (gGCT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Gamma-Glutamylcyclotransferase (gGCT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Gamma-Glutamylcyclotransferase (gGCT) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Gamma-Glutamylcyclotransferase (gGCT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Gamma-Glutamylcyclotransferase (gGCT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Gamma-Glutamylcyclotransferase (gGCT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Gamma-Glutamylcyclotransferase (gGCT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Gamma-Glutamylcyclotransferase (gGCT) ELISA Kit Customized Service Offer
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