Gem Associated Protein 7 (GEMIN7)
GEMIN7 is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear "gems" (Gemini of Cajal bodies), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene.
GEMIN7 is a component of the SMN complex and colocalizes with SMN in the cytoplasm and in gems. Binding experiments showed that GEMIN7 interacts directly with SMN and GEMIN6 and mediates the association of GEMIN6 with the SMN complex. The RG repeats were necessary for its interaction with SMN. GEMIN7 also interacted with several Sm proteins of snRNPs, particularly with SmE (SNRPE).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Gem Associated Protein 7 (GEMIN7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Gem Associated Protein 7 (GEMIN7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Gem Associated Protein 7 (GEMIN7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Gem Associated Protein 7 (GEMIN7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Gem Associated Protein 7 (GEMIN7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Gem Associated Protein 7 (GEMIN7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Gem Associated Protein 7 (GEMIN7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Gem Associated Protein 7 (GEMIN7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Gem Associated Protein 7 (GEMIN7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Gem Associated Protein 7 (GEMIN7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Gem Associated Protein 7 (GEMIN7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Gem Associated Protein 7 (GEMIN7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Gem Associated Protein 7 (GEMIN7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Gem Associated Protein 7 (GEMIN7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Gem Associated Protein 7 (GEMIN7) ELISA Kit Customized Service Offer
  1. "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex."J. Biol. Chem. 277:31957-31962(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs."Cell 135:497-509(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  7. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  8. "The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure."Structure 13:883-892(2005) [PubMed] [Europe PMC] [Abstract]