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Gem Associated Protein 6 (GEMIN6)

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SIP2

Gem Associated Protein 6 (GEMIN6)
CCC J046
HGNC 20044
MGI 1914492
PubMed 11748230
RGD 1311168
UniProt Q8WXD5
Wiki GEMIN6
GEMIN6 is part of a large macromolecular complex, localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN , GEMIN2 (SIP1), GEMIN3 (DDX20), GEMIN4, and GEMIN5.
The deduced 167-amino acid protein has a predicted molecular mass of 18 kD and shares 86% sequence identity with the mouse homolog. GEMIN6 migrates as a 16-kD protein by Western blot analysis of affinity purified SMN macromolecular complexes. Immunofluorescence microscopy of HeLa cells showed GEMIN6 staining in both the cytoplasm and the nucleus with a high concentration in gems.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Gem Associated Protein 6 (GEMIN6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Gem Associated Protein 6 (GEMIN6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Gem Associated Protein 6 (GEMIN6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Gem Associated Protein 6 (GEMIN6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Gem Associated Protein 6 (GEMIN6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Gem Associated Protein 6 (GEMIN6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Gem Associated Protein 6 (GEMIN6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Gem Associated Protein 6 (GEMIN6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Gem Associated Protein 6 (GEMIN6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Gem Associated Protein 6 (GEMIN6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Gem Associated Protein 6 (GEMIN6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Gem Associated Protein 6 (GEMIN6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Gem Associated Protein 6 (GEMIN6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Gem Associated Protein 6 (GEMIN6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Gem Associated Protein 6 (GEMIN6) ELISA Kit Customized Service Offer
  1. "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component."J. Biol. Chem. 277:7540-7545(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex."J. Biol. Chem. 277:31957-31962(2002) [PubMed] [Europe PMC] [Abstract]
  6. "An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs."Cell 135:497-509(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure."Structure 13:883-892(2005) [PubMed] [Europe PMC] [Abstract]