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Growth Factor, Augmenter Of Liver Regeneration (GFER)

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ERV1; ALR; HERV1; HPO; HPO1; HPO2; HSS; FAD-linked sulfhydryl oxidase ALR; Augmenter of liver regeneration

Growth Factor, Augmenter Of Liver Regeneration (GFER)
CCC J039
HGNC 4236
MGI 107757
PubMed 11709497
RGD 61845
UniProt P55789
Wiki GFER
The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS).
GFER resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Growth Factor, Augmenter Of Liver Regeneration (GFER) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Growth Factor, Augmenter Of Liver Regeneration (GFER) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Growth Factor, Augmenter Of Liver Regeneration (GFER) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Growth Factor, Augmenter Of Liver Regeneration (GFER) CLIA Kit Customized Service Offer
n/a ELISA Kit for Growth Factor, Augmenter Of Liver Regeneration (GFER) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ039Mu01 Recombinant Growth Factor, Augmenter Of Liver Regeneration (GFER) Positive Control; Immunogen; SDS-PAGE; WB.
RPJ039Mu02 Recombinant Growth Factor, Augmenter Of Liver Regeneration (GFER) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ039Mu01 Polyclonal Antibody to Growth Factor, Augmenter Of Liver Regeneration (GFER) WB; IHC; ICC; IP.
PAJ039Mu02 Polyclonal Antibody to Growth Factor, Augmenter Of Liver Regeneration (GFER) WB; IHC; ICC; IP.
Assay Kits SEJ039Mu ELISA Kit for Growth Factor, Augmenter Of Liver Regeneration (GFER) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Growth Factor, Augmenter Of Liver Regeneration (GFER) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Growth Factor, Augmenter Of Liver Regeneration (GFER) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Growth Factor, Augmenter Of Liver Regeneration (GFER) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Growth Factor, Augmenter Of Liver Regeneration (GFER) CLIA Kit Customized Service Offer
n/a ELISA Kit for Growth Factor, Augmenter Of Liver Regeneration (GFER) ELISA Kit Customized Service Offer
  1. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and sequence analysis of human genomic DNA of augmenter of liver regeneration hepatitis."Zhonghua Gan Zang Bing Za Zhi 8:12-14(2000) [PubMed] [Europe PMC] [Abstract]
  4. "A new human gene located in the PKD1 region of chromosome 16 is a functional homologue to ERV1 of yeast."Genomics 29:690-697(1995) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of hepatopoietin dimerization, its interacting regions and alternative splicing of its transcription."Eur. J. Biochem. 269:3888-3893(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Augmenter of liver regeneration: substrate specificity of a flavin-dependent oxidoreductase from the mitochondrial intermembrane space."Biochemistry 48:4828-4837(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Disulfide bond formation: sulfhydryl oxidase ALR controls mitochondrial biogenesis of human MIA40."Traffic 14:309-320(2013) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Structure of the human sulfhydryl oxidase augmenter of liver regeneration and characterization of a human mutation causing an autosomal recessive myopathy."Biochemistry 49:6737-6745(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Molecular recognition and substrate mimicry drive the electron-transfer process between MIA40 and ALR."Proc. Natl. Acad. Sci. U.S.A. 108:4811-4816(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An electron-transfer path through an extended disulfide relay system: the case of the redox protein ALR."J. Am. Chem. Soc. 134:1442-1445(2012) [PubMed] [Europe PMC] [Abstract]
  14. "The mitochondrial disulfide relay system protein GFER is mutated in autosomal-recessive myopathy with cataract and combined respiratory-chain deficiency."Am. J. Hum. Genet. 84:594-604(2009) [PubMed] [Europe PMC] [Abstract]