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Gem Interacting Protein (GMIP)

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Gem Interacting Protein (GMIP)
CCC J019
HGNC 24852
MGI 1926066
PubMed 22438581
RGD 1565577
UniProt Q9P107
GMIP encodes a member of the ARHGAP family of Rho/Rac/Cdc42-like GTPase activating proteins. The encoded protein interacts with the Ras-related protein Gem through its N-terminal domain. Separately, it interacts with RhoA through a RhoGAP domain, and stimulates RhoA-dependent GTPase activity. Alternatively spliced variants that encode different protein isoforms have been described but their full-length nature has not been determined.
The deduced 970-amino acid protein contains an alpha-helical N-terminal domain with a coiled-coil region, followed by a central cysteine-rich domain and a Rho GTPase-activating protein (RhoGAP) domain. Northern blot analysis detected ubiquitous expression of a 4-kb GMIP transcript and tissue-specific expression of other GMIP transcripts.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Gem Interacting Protein (GMIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Gem Interacting Protein (GMIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Gem Interacting Protein (GMIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Gem Interacting Protein (GMIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Gem Interacting Protein (GMIP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Gem Interacting Protein (GMIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Gem Interacting Protein (GMIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Gem Interacting Protein (GMIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Gem Interacting Protein (GMIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Gem Interacting Protein (GMIP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Gem Interacting Protein (GMIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Gem Interacting Protein (GMIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Gem Interacting Protein (GMIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Gem Interacting Protein (GMIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Gem Interacting Protein (GMIP) ELISA Kit Customized Service Offer
  1. "A novel Rho GTPase-activating-protein interacts with Gem, a member of the Ras superfamily of GTPases."Biochem. J. 367:57-65(2002) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "Crystal structure of the N-terminal domain of the GEM interacting protein."Submitted (MAR-2011) to the PDB data bank