Perineurial Fibroblasts

Perineurial fibroblasts are a type of cell that is located in the perineurium, which is the protective layer that surrounds nerves. Perineurial fibroblasts are of mesenchymal origin and form the perineurium. The perineurium plays an important role in maintaining the integrity of the internal peripheral nerve environment by creating a physical barrier that, under physiologic condition, limits the entry of biologically active proteins, infectious agents, and blood-borne cells into the nerve bundles. 

These fibroblasts play a crucial role in providing structural support to the nerves and helping to maintain their integrity. They also play a role in the repair and regeneration of nerves after injury. Perineurial fibroblasts are essential for the proper functioning of the nervous system and are important for overall nerve health.