Cervical Epithelial Cells (CrEC)

Cervical epithelial cells (CrEC) are located in the cervix, used to maintain the integrity of the structure of the cervix, limiting the role of molecules and cell material through the cell to enter the channel of the cervix. Studies have indicated that patients infected with human papilloma can cause inflammation of the epithelial cell layer, which may result in the occurrence of cervical cancer.The stem-cell-abundant proteins (Nanog, NS and Msi1) have roles in the carcinogenesis of cervical epithelial cells and regulate the cell differentiation, proliferation and asymmetric division, and maintain cancer cell pluripotency. Each protein may have an important and unique role in each step of the transformation process from normal cervical epithelial cells to malignant cells.Cultured CrEC is a useful in vitro model to study the pathophysiology and cervical carcinoma of the cervix.