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Grainyhead Like Protein 2 (GRHL2)

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DFNA28; TFCP2L3; BOM; Deafness,Autosomal Dominant 28; Transcription Factor CP2-Like 3; Brother of mammalian grainyhead

Grainyhead Like Protein 2 (GRHL2)
CCC H964
HGNC 2799
MGI 2182543
PubMed 23610592
RGD 1561191
UniProt Q6ISB3
TFCP2L3 contains a 4,793-bp open reading frame encoding a protein of 625 amino acids that shares 34% identity in the DNA-binding region and 27% overall identity with TFCP2.
Northern blot analysis of human tissues detected a major 6.5-kb transcript and a minor 8.4-kb transcript in prostate. Analysis of a human multiple tissue Northern blot confirmed that TFCP2L3 was highly expressed in the prostate, as well as the placenta, and also showed lower level expression in a variety of epithelial tissues such as thymus, kidney, lung, salivary gland, mammary gland, and digestive tract. Northern blot analyses and in situ hybridization studies showed that mouse Tfcp2l3 was expressed in many epithelial tissues, including cells lining the cochlear duct.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Grainyhead Like Protein 2 (GRHL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Grainyhead Like Protein 2 (GRHL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Grainyhead Like Protein 2 (GRHL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Grainyhead Like Protein 2 (GRHL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Grainyhead Like Protein 2 (GRHL2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Grainyhead Like Protein 2 (GRHL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Grainyhead Like Protein 2 (GRHL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Grainyhead Like Protein 2 (GRHL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Grainyhead Like Protein 2 (GRHL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Grainyhead Like Protein 2 (GRHL2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Grainyhead Like Protein 2 (GRHL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Grainyhead Like Protein 2 (GRHL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Grainyhead Like Protein 2 (GRHL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Grainyhead Like Protein 2 (GRHL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Grainyhead Like Protein 2 (GRHL2) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Mutation of a transcription factor, TFCP2L3, causes progressive autosomal dominant hearing loss, DFNA28."Hum. Mol. Genet. 11:2877-2885(2002) [PubMed] [Europe PMC] [Abstract]
  4. "A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead."Mech. Dev. 114:37-50(2002) [PubMed] [Europe PMC] [Abstract]
  5. "The identification and characterization of human sister-of-mammalian grainyhead (SOM) expands the grainyhead-like family of developmental transcription factors."Biochem. J. 370:953-962(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Regulation of the hTERT promoter activity by MSH2, the hnRNPs K and D, and GRHL2 in human oral squamous cell carcinoma cells."Oncogene 28:565-574(2009) [PubMed] [Europe PMC] [Abstract]
  7. "The transcription factor grainyhead-like 2 regulates the molecular composition of the epithelial apical junctional complex."Development 137:3835-3845(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Grainyhead-like 2 enhances the human telomerase reverse transcriptase gene expression by inhibiting DNA methylation at the 5'-CpG island in normal human keratinocytes."J. Biol. Chem. 285:40852-40863(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Grainyhead-like 2 (GRHL2) inhibits keratinocyte differentiation through epigenetic mechanism."Cell Death Dis. 3:E450-E450(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Mutations in GRHL2 result in an autosomal-recessive ectodermal Dysplasia syndrome."Am. J. Hum. Genet. 95:308-314(2014) [PubMed] [Europe PMC] [Abstract]