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G-Rich RNA Sequence Binding Factor 1 (GRSF1)

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G-rich sequence factor 1

G-Rich RNA Sequence Binding Factor 1 (GRSF1)
CCC H958
HGNC 4610
MGI 106479
PubMed 23473034
RGD 1310858
UniProt Q12849
The GRSF1 cDNA has a long 3-prime untranslated region containing 2 polyadenylation signals. The open reading frame encodes a deduced 424-amino acid protein with a calculated molecular mass of 48 kD. The protein contains 3 RNA recognition motifs and 2 auxiliary domains. Northern blot analysis indicated 2 predominant mRNAs of 1.7 and 2.8 kb. Indirect immunofluorescence microscopy with anti-GRSF1 monoclonal antibody and in vivo UV crosslinking experiments suggested that GRSF1 is a cytosolic poly(A)+ mRNA-binding protein.
Grsf1 upregulated Gpx4 UTR-dependent reporter gene expression, recruited mitochondrial Gpx4 mRNA to translationally active polysomes, and coimmunoprecipitated with Gpx4 mRNA.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G-Rich RNA Sequence Binding Factor 1 (GRSF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G-Rich RNA Sequence Binding Factor 1 (GRSF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G-Rich RNA Sequence Binding Factor 1 (GRSF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G-Rich RNA Sequence Binding Factor 1 (GRSF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for G-Rich RNA Sequence Binding Factor 1 (GRSF1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G-Rich RNA Sequence Binding Factor 1 (GRSF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G-Rich RNA Sequence Binding Factor 1 (GRSF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G-Rich RNA Sequence Binding Factor 1 (GRSF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G-Rich RNA Sequence Binding Factor 1 (GRSF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for G-Rich RNA Sequence Binding Factor 1 (GRSF1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G-Rich RNA Sequence Binding Factor 1 (GRSF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G-Rich RNA Sequence Binding Factor 1 (GRSF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G-Rich RNA Sequence Binding Factor 1 (GRSF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G-Rich RNA Sequence Binding Factor 1 (GRSF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for G-Rich RNA Sequence Binding Factor 1 (GRSF1) ELISA Kit Customized Service Offer
  1. "GRSF-1: a poly(A)+ mRNA binding protein which interacts with a conserved G-rich element."Nucleic Acids Res. 22:2334-2343(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]