Hepatitis A Virus Cellular Receptor 2 (HAVCR2)

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KIM-3; TIM3; TIMD3; Tim-3; T-cell membrane protein 3; T-cell immunoglobulin mucin receptor 3; T-cell immunoglobulin and mucin domain-containing protein 3

Hepatitis A Virus Cellular Receptor 2 (HAVCR2)
Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.The deduced 301-amino acid type I membrane protein, 63% identical overall and 77% identical in the cytoplasmic domain, has an Ig variable-like domain, a mucin-like domain consisting of 31% serine and threonine residues, and a cytoplasmic domain with a tyrosine phosphorylation motif.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH930Hu01 Recombinant Hepatitis A Virus Cellular Receptor 2 (HAVCR2) Positive Control; Immunogen; SDS-PAGE; WB.
EPH930Hu61 Eukaryotic Hepatitis A Virus Cellular Receptor 2 (HAVCR2) Positive Control; Immunogen; SDS-PAGE; WB.
APH930Hu61 Active Hepatitis A Virus Cellular Receptor 2 (HAVCR2) Cell culture; Activity Assays.
Antibodies MAH930Hu21 Monoclonal Antibody to Hepatitis A Virus Cellular Receptor 2 (HAVCR2) WB; IHC; ICC; IP.
PAH930Hu01 Polyclonal Antibody to Hepatitis A Virus Cellular Receptor 2 (HAVCR2) WB,FCM
LAH930Hu72 Biotin-Linked Monoclonal Antibody to Hepatitis A Virus Cellular Receptor 2 (HAVCR2) WB; IHC; ICC.
MAH930Hu22 Monoclonal Antibody to Hepatitis A Virus Cellular Receptor 2 (HAVCR2) WB; IHC; ICC; IP.
MAH930Hu23 Monoclonal Antibody to Hepatitis A Virus Cellular Receptor 2 (HAVCR2) WB; IHC; ICC; IP.
MAH930Hu24 Monoclonal Antibody to Hepatitis A Virus Cellular Receptor 2 (HAVCR2) WB; IHC; ICC; IP.
MAH930Hu25 Monoclonal Antibody to Hepatitis A Virus Cellular Receptor 2 (HAVCR2) WB; IHC; ICC; IP.
MAH930Hu27 Monoclonal Antibody to Hepatitis A Virus Cellular Receptor 2 (HAVCR2) WB; IHC; ICC; IP.
MAH930Hu26 Monoclonal Antibody to Hepatitis A Virus Cellular Receptor 2 (HAVCR2) WB; IHC; ICC; IP.
Assay Kits SEH930Hu ELISA Kit for Hepatitis A Virus Cellular Receptor 2 (HAVCR2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins EPH930Mu61 Eukaryotic Hepatitis A Virus Cellular Receptor 2 (HAVCR2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Hepatitis A Virus Cellular Receptor 2 (HAVCR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hepatitis A Virus Cellular Receptor 2 (HAVCR2) Polyclonal Antibody Customized Service Offer
Assay Kits SEH930Mu ELISA Kit for Hepatitis A Virus Cellular Receptor 2 (HAVCR2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hepatitis A Virus Cellular Receptor 2 (HAVCR2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hepatitis A Virus Cellular Receptor 2 (HAVCR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hepatitis A Virus Cellular Receptor 2 (HAVCR2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hepatitis A Virus Cellular Receptor 2 (HAVCR2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hepatitis A Virus Cellular Receptor 2 (HAVCR2) ELISA Kit Customized Service Offer
  1. "Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease."Nature 415:536-541(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance."Nat. Immunol. 4:1093-1101(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity."Nat. Immunol. 6:1245-1252(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]