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Hepatitis B Virus X Interacting Protein (HBXIP)

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LAMTOR5; XIP; HBx-Interacting Protein; Ragulator complex protein LAMTOR5; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5

Hepatitis B Virus X Interacting Protein (HBXIP)
CCC H929
HGNC 17955
MGI 1915826
PubMed 23291272
RGD 1305005
UniProt O43504
Wiki HBXIP
HBXIP encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus.
The deduced 91-amino acid protein has a calculated molecular mass of 9.6 kD. It contains a putative leucine zipper motif and may form an amphipathic helix. HBXIP also has 2 putative threonine phosphorylation sites. Northern blot analysis detected a 0.7-kb transcript in all tissues tested, with highest expression in skeletal and cardiac muscle.HBXIP expression in differentiated hepatocellular carcinoma cells reduced wildtype HBV replication to levels observed following infection with an HBX-minus virus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hepatitis B Virus X Interacting Protein (HBXIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hepatitis B Virus X Interacting Protein (HBXIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hepatitis B Virus X Interacting Protein (HBXIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hepatitis B Virus X Interacting Protein (HBXIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hepatitis B Virus X Interacting Protein (HBXIP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hepatitis B Virus X Interacting Protein (HBXIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hepatitis B Virus X Interacting Protein (HBXIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hepatitis B Virus X Interacting Protein (HBXIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hepatitis B Virus X Interacting Protein (HBXIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hepatitis B Virus X Interacting Protein (HBXIP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hepatitis B Virus X Interacting Protein (HBXIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hepatitis B Virus X Interacting Protein (HBXIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hepatitis B Virus X Interacting Protein (HBXIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hepatitis B Virus X Interacting Protein (HBXIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hepatitis B Virus X Interacting Protein (HBXIP) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication."J. Virol. 72:1737-1743(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. , Submitted (JUL-2005) to UniProtKB
  5. "HBXIP functions as a cofactor of survivin in apoptosis suppression."EMBO J. 22:2729-2740(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Human ATP-dependent RNA/DNA helicase hSuv3p interacts with the cofactor of survivin HBXIP."FEBS J. 272:5008-5019(2005) [PubMed] [Europe PMC] [Abstract]
  7. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Ragulator is a GEF for the Rag GTPases that signal amino acid levels to mTORC1."Cell 150:1196-1208(2012) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1."Nature 519:477-481(2015) [PubMed] [Europe PMC] [Abstract]
  13. "Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1."Science 347:188-194(2015) [PubMed] [Europe PMC] [Abstract]
  14. "Structural characterization of HBXIP: the protein that interacts with the anti-apoptotic protein survivin and the oncogenic viral protein HBx."J. Mol. Biol. 405:331-340(2011) [PubMed] [Europe PMC] [Abstract]